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Geometry Scaling for Externally Balanced Cascade Deterministic Lateral Displacement Microfluidic Separation of Multi-Size Particles. | LitMetric

AI Article Synopsis

  • - The paper discusses the importance of particle size in non-invasive monitoring using IoT-based wearable microfluidic sensors and proposes a new method for size fractionation using Deterministic Lateral Displacement (DLD).
  • - It introduces an externally balanced multi-section cascade DLD design that enhances the dynamic range for separating different particle sizes by varying section dimensions.
  • - The authors provide a robust model that helps designers understand trade-offs between device size and performance, showcasing how cascading sections can improve size separation resolution while considering practical fabrication constraints.

Article Abstract

To non-invasively monitor personal biological and environmental samples in Internet of Things (IoT)-based wearable microfluidic sensing applications, the particle size could be key to sensing, which emphasizes the need for particle size fractionation. Deterministic lateral displacement (DLD) is a microfluidic structure that has shown great potential for the size fractionation of micro- and nano-sized particles. This paper introduces a new externally balanced multi-section cascade DLD approach with a section-scaling technique aimed at expanding the dynamic range of particle size separation. To analyze the design tradeoffs of this new approach, a robust model that also accounts for practical fabrication limits is presented, enabling designers to visualize compromises between the overall device size and the achievement of various performance goals. Furthermore, results show that a wide variety of size fractionation ranges and size separation resolutions can be achieved by cascading multiple sections of an increasingly smaller gap size and critical separation dimension. Model results based on DLD theoretical equations are first presented, followed by model results that apply the scaling restrictions associated with the second order of effects, including practical fabrication limits, the gap/pillar size ratio, and pillar shape.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10972160PMC
http://dx.doi.org/10.3390/mi15030405DOI Listing

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