AI Article Synopsis
- Bone regeneration in diseases involving bone loss remains a challenge, as traditional therapies often yield suboptimal results in terms of effectiveness and treatment duration.* -
- Extracellular vesicles (EVs) have emerged as a promising alternative, offering superior therapeutic effects for bone regeneration by facilitating tissue repair and regulating the immune response.* -
- This paper provides a comprehensive review on the types of EVs, their sources, methods of application, and how they can be utilized in combination with scaffold biomaterials to enhance bone regeneration.*
Article Abstract
Promoting the efficiency of bone regeneration in bone loss diseases is a significant clinical challenge. Traditional therapies often fail to achieve better therapeutic outcomes and shorter treatment times. However, in recent years, extracellular vesicles (EVs) have gained significant attention due to their exceptional osteogenic function in bone regeneration and superior therapeutic effects compared to traditional cell therapy. EVs have emerged as a promising therapy for tissue defect regeneration due to their various physiological functions, such as regulating the immune response and promoting tissue repair and regeneration. Moreover, EVs have good biocompatibility, low immunogenicity, and long-term stability, and can be improved through pretreatment and other methods. Studies investigating the mechanisms by which extracellular vesicles promote bone regeneration and applying EVs from different sources using various methods to animal models of bone defects have increased. Therefore, this paper reviews the types of EVs used for bone regeneration, their sources, roles, delivery pathways, scaffold biomaterials, and applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10970826 | PMC |
| http://dx.doi.org/10.3390/ijms25063480 | DOI Listing |
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