AI Article Synopsis
- - Coronary vasomotor disorders (CVD) involve temporary over-contraction of coronary smooth muscle, contributing to heart issues like ischemia and myocardial infarction, even when arteries are not blocked.
- - The acetylcholine (ACh) test is the main method for diagnosing CVD and offers important insights for treatment and predicting outcomes, but concerns about safety limit its use in everyday medical settings.
- - This review aims to explain the causes of CVD, evaluate the safety and effectiveness of the ACh test, and discuss new management strategies tailored to individual patients with CVD.
Article Abstract
Coronary vasomotor disorders (CVD) are characterized by transient hypercontraction of coronary vascular smooth muscle cells, leading to hypercontraction of epicardial and/or microvascular coronary circulation. CVDs play a relevant role in the pathogenesis of ischemia, angina and myocardial infarction with non-obstructive coronary arteries. Invasive provocative testing with intracoronary Acetylcholine (ACh) administration is the gold standard tool for addressing CVD, providing relevant therapeutic and prognostic implications. However, safety concerns preclude the widespread incorporation of the ACh test into clinical practice. The purpose of this review is to shed light on the pathophysiology underlying CVD and on the clinical role of the ACh test, focusing on safety profile and prognostic implications. We will also discuss contemporary evidence on the management of CVD and the role of the ACh test in driving a personalized approach of patients with CVD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10970947 | PMC |
| http://dx.doi.org/10.3390/life14030292 | DOI Listing |
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