Postbiotics from Alleviate Intestinal Inflammation by Promoting the Expansion of Intestinal Stem Cells in . Typhimurium-Induced Mice.

Previous studies have demonstrated that plays beneficial roles in modulating the gut microbiota, enhancing the intestinal barrier, and promoting animal growth. Postbiotics have a similar or even superior effect in protecting intestinal health compared to probiotics due to their excellent stability, extended shelf life, and safety. However, the protective effects and underlying mechanism of postbiotics from in intestinal inflammation remain unclear. In this study, we demonstrated the beneficial impact of postbiotics from on intestinal health by establishing a Typhimurium-induced intestinal inflammation model in mice, which included inactivated bacteria and supernatant. The results revealed that the probiotics and postbiotics from increased the survival rate and body weight of . Typhimurium-induced mice, increased the level of IL-10, and decreased the levels of TNF-α and IL-6, thereby alleviating intestinal inflammation. Meanwhile, treatment with postbiotics decreased the levels of D-LA, DAO, and LPS and promoted the expression of Occludin, ZO-1, and Claudin-1 in the serum and jejunum, suggesting an improvement in intestinal barrier function by postbiotics. Additionally, the postbiotics modulated gut microbial diversity, increased the ratio of and , and restored the abundance of , , and in . Typhimurium-infected mice. Moreover, postbiotics from promoted the expansion of intestinal stem cells (ISCs) and increased the numbers of Paneth and Goblet cells. Taken together, these data revealed the beneficial role of postbiotics from in protecting against intestinal inflammation by promoting the expansion of ISCs.