AI Article Synopsis
- Parapoxviruses are viruses that primarily affect ruminants and usually have a limited host range, but the pseudocowpox virus (PCPV) can infect humans as well.
- A new case of PCPV was reported in northern Russia (Irkutsk region), occurring in herds without immune animals or new arrivals.
- The study confirmed the Irkutsk isolate as PCPV through genetic analysis, showing a close relation to PCPV strains from Europe and the USA, although the B2L gene's conservation makes it hard to link strains to their geographic origins.
Article Abstract
Parapoxviruses are worldwide epitheliotropic viruses that affect ruminants. Viruses of this genus have a narrow host range; however, the pseudocowpox virus (PCPV) also infects humans. Unfortunately, these cases are not well documented, and the epidemiology and the properties of the causative agents are not properly described. Here, we report the first case of PCPV in northern Russia (the Irkutsk region). The infection occurred in non-immune herds where no new arrivals of animals had been reported. Moreover, clinical signs of infection (skin lesions) were observed in humans. Based on the nucleotide identity and phylogenetic analysis of the partial-length B2L gene, the Irkutsk 2019 isolate was classified as PCPV. Phylogenetic analysis based on the nucleotide sequence of the B2L gene fragment of PCPV revealed a close phylogenetic relationship between the Irkutsk 2019 isolate and the PCPV strains isolated in Europe and the USA. The high degree of conservatism of the B2L gene does not allow for finding a correlation between their geographical origin and the results of phylogenetic analysis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10967631 | PMC |
| http://dx.doi.org/10.3390/ani14060969 | DOI Listing |
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