AI Article Synopsis
- Chicken breeders are focusing on intensive genetic selection to enhance growth rates, leading to new breeds with increased fat accumulation.
- A study utilized RNA-seq to analyze fat tissue at various growth stages to understand how genetics influence fat development in broilers.
- Key findings indicated critical periods for fat growth and identified several candidate genes that could be important for future breeding and research on chicken adipose tissue development.
Article Abstract
In an effort to enhance growth rates, chicken breeders have undertaken intensive genetic selection. In the selection process, the primary aim is to accelerate growth, inadvertently leading to new chicken breeds having an increased capacity for rapid adipose tissue accumulation. However, little is known about the relationship between changes in gene expression and adipose tissue accumulation and deposition in chickens. Therefore, in this study, RNA-seq analysis was utilized, and transcriptome data were obtained from the abdominal fat, thoracic subcutaneous fat, and clavicular fat on day 1 (d1), day 4, day 7, day 11, and day 15 to reveal the molecular mechanisms regulating the development and deposition of different adipose tissues in broiler chicks. The results showed that the key period for adipocyte differentiation and proliferation was between d4 and d7 (abdominal fat development) and between d1 and d4 (chest subcutaneous fat and clavicular fat). In addition, candidate genes such as , , , , and related to adipose tissue growth and development were identified. Further, genes (, , , , , and ) associated with the distribution of adipose tissue were identified, and genes (, , and ) related to adipose tissue growth were also identified. Taken together, the results from this study provide the basis for future studies on the mechanisms regulating adipose tissue development in chickens. Further, the candidate genes identified could be used in the selection process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10967598 | PMC |
| http://dx.doi.org/10.3390/ani14060899 | DOI Listing |
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