Brain tumors represent some of the most aggressive malignancies [...].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10968866 | PMC |
| http://dx.doi.org/10.3390/brainsci14030224 | DOI Listing |
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Genes related to neural tube defects and glioblastoma.
Sci Rep
January 2025
Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Key Laboratory of Coal Environmental Pathogenicity and Prevention (Ministry of Education, China, Shanxi Medical University, No. 56, Xinjian South Road, Yingze District, Taiyuan City, 030000, Shanxi Province, China.
There are many similarities between early embryonic development and tumorigenesis. The occurrence of neural tube defects (NTDs) and glioblastoma (GBM) are both related to the abnormal development of neuroectodermal cells. To obtain genes related to both NTDs and GBM, as well as small molecule drugs with potential clinical application value.
View Article and Find Full Text PDFOncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma.
Nat Commun
January 2025
Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Oncolytic viruses (OVs) emerge as a promising cancer immunotherapy. However, the temporal impact on tumor cells and the tumor microenvironment, and the nature of anti-tumor immunity post-therapy remain largely unclear. Here we report that CD4 T cells are required for durable tumor control in syngeneic murine models of glioblastoma multiforme after treatment with an oncolytic herpes simplex virus (oHSV) engineered to express IL-12.
View Article and Find Full Text PDFCritical Review of Ketogenic Diet Throughout the Cancer Continuum for Neuroglioma: Insights from a Medical Nutrition Therapy (MNT) Perspective.
Curr Nutr Rep
January 2025
Department of Vascular Surgery, Mount Sinai Hospital, 1468 Madison Ave, New York, NY, 10029, USA.
PURPOSE OF REVIEW: A Ketogenic diet (KD; a diet comprised of 75% fat, 20% protein and 5% carbohydrates) has gained much popularity in recent years, especially regarding neurogliomas (or "gliomas"). This review critically assesses literature on the application of KD throughout the cancer continuum from a Medical Nutrition Therapy (MNT) perspective. RECENT FINDINGS: 2021 revised classification standards for Central Nervous System (CNS) tumors are available.
View Article and Find Full Text PDFSymptom Clusters in Patients with Brain Tumors: A Systematic Review.
Semin Oncol Nurs
January 2025
Pelvic Floor Diseases Center, West China Tianfu Hospital, Sichuan University, Chengdu, China. Electronic address:
Objectives: To identify composition, predictors, outcomes and stability of symptom clusters in brain tumor patients and to examine assessment tools and statistical methods.
Methods: The PubMed, Web of Science, Embase, CINAHL, and Cochrane Library databases were systematically searched. Two reviewers independently screened the titles, abstracts and full texts.
[Current Consensus and Challenges of Fluorescence Imaging Technology in the Surgery of Spinal Intramedullary Tumors].
No Shinkei Geka
January 2025
Department of Neurosurgery, Osaka Medical and Pharmaceutical University.
Surgery for spinal intramedullary tumors remains a major challenge for neurosurgeons. Successful surgery requires experience, skill, and intraoperative imaging support. Fluorescence imaging technology has become a valuable support in neurosurgical procedures of not only the brain but also the spinal cord.
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