Prenatal alcohol exposure is responsible for increasing chronic disease risk in later life, including obesity and metabolic syndrome. Alcohol drinking may compromise endogenous antioxidant capacity, causing an increase in free radicals and reactive oxygen species in the newborn. Excessive reactive oxygen species could attack the cellular proteins, lipids, and nucleic acids, leading to cellular dysfunction. Moreover, oxidative stress could play a crucial role in the altered synthesis and release of neurotrophins and progressive mitochondrial modifications with uncontrolled apoptosis. This narrative review aims to underline the important role of alcohol abuse in oxidative stress events and consequent metabolic and neurocognitive impairments in children exposed to alcohol during gestational life.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10968828 | PMC |
| http://dx.doi.org/10.3390/children11030269 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.
JAMA Netw Open
December 2024
Department of Psychological and Brain Sciences, Washington University in St Louis, Missouri.
Importance: The extent to which neuroanatomical variability associated with early substance involvement, which is associated with subsequent risk for substance use disorder development, reflects preexisting risk and/or consequences of substance exposure remains poorly understood.
Objective: To examine neuroanatomical features associated with early substance use initiation and to what extent associations may reflect preexisting vulnerability.
Design, Setting, And Participants: Cohort study using data from baseline through 3-year follow-up assessments of the ongoing longitudinal Adolescent Brain Cognitive Development Study.
Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders.
Respir Res
January 2025
Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, School of Medicine, Wayne State University, 275 E Hancock St, Rm 195, Detroit, MI, 48201, USA.
Current fetal alcohol spectrum disorders (FASD) studies primarily focus on alcohol's actions on the fetal brain although respiratory infections are a leading cause of morbidity/mortality in newborns. The limited studies examining the pulmonary adaptations in FASD demonstrate decreased surfactant protein A and alveolar macrophage phagocytosis, impaired differentiation, and increased risk of Group B streptococcal pneumonia with no study examining sexual dimorphism in adaptations. We hypothesized that developmental alcohol exposure in pregnancy will lead to sexually dimorphic fetal lung morphological and immune adaptations.
View Article and Find Full Text PDFThe burden of generational harm due to alcohol use in Tanzania: A mixed method study of pregnant women.
PLOS Glob Public Health
December 2024
Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America.
Background: Rates of prenatal alcohol use in Sub-Saharan Africa (SSA) are increasing despite regulatory bodies urging pregnant women to abstain from alcohol. Tanzania has minimal policies, interventions, and educational programs addressing prenatal alcohol exposure. Consequently, a considerable number of mothers and their fetuses are exposed to alcohol, leading to serious health consequences like fetal alcohol spectrum disorder (FASD).
View Article and Find Full Text PDFHigh-Potency Prenatal Cannabis Exposure and Birth Outcome Measures.
Children (Basel)
November 2024
Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Pregnant women have limited information on the impact of prenatal cannabis exposure (PCE) alone. Our aim was to determine if PCE, without alcohol, tobacco, or illicit drug use, is associated with altered birth outcome measures in obstetrically low-risk women. In this observational cohort study, pregnant women were recruited between 2019 and 2022 from communities in Washington and Oregon, USA, and enrolled following their first trimester.
View Article and Find Full Text PDFRole of Drinking Attitudes and Trait Impulsivity in Prenatal Alcohol Craving and Consumption in Mothers of Reproductive Age.
Subst Use Misuse
January 2025
Substance Use, Gender and Applied Research, RTI International, Research Triangle Park, NC, USA.
Recognizing the severe consequences of alcohol consumption during pregnancy, such as fetal alcohol spectrum disorders (FASDs), the present study explored the role of drinking attitudes, trait impulsivity, and decision-making toward instant gratification in alcohol craving and consumption during pregnancy among mothers of reproductive age. Utilizing participants from Amazon Mechanical Turk ( = 141), we first categorized mothers into three groups: those who neither craved nor consumed alcohol during their last pregnancy, those who craved but did not consume, and those who craved and consumed alcohol. Using binomial logistic regression, we then examined what factors, if any, could differentiate between (a) mothers who craved alcohol during pregnancy and those who did not and (b) mothers who resisted alcohol cravings and those who yielded to them.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!