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| http://dx.doi.org/10.1038/s41598-024-57683-x | DOI Listing |
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Surgical correction of a chin-on-abdomen deformity due to ankylosing spinal deformity and obesity: illustrative case.
J Neurosurg Case Lessons
January 2025
Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois.
Background: Kyphotic spinal deformity is a complication of ankylosing spondylitis (AS). In rare cases, particularly in obese patients, the deformity might extend to the cervicothoracic spine, resulting in a severe "chin-on-abdomen" deformity. This condition severely impairs quality of life by affecting gaze, swallowing, and causing chronic pain.
View Article and Find Full Text PDFEffect of power training on function and body composition in older women with probable sarcopenia. A study protocol for a randomized controlled trial.
PLoS One
January 2025
Department of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain.
Background: Sarcopenia is a clinical syndrome characterized by the loss of muscle mass and strength. Hormonal changes that occur early in women may influence protein synthesis and promote muscle atrophy, leading to probable sarcopenia, defined as a loss of muscle strength without an obvious decrease in muscle mass. Various types of exercise have already proven effective in treating sarcopenia.
View Article and Find Full Text PDFNMR spectroscopy derived plasma biomarkers of inflammation in human populations: Influences of age, sex and adiposity.
PLoS One
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Australian National Phenome Center and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.
Understanding the distribution and variation in inflammatory markers is crucial for advancing our knowledge of inflammatory processes and evaluating their clinical utility in diagnosing and monitoring acute and chronic disease. 1H NMR spectroscopy of blood plasma and serum was applied to measure a composite panel of inflammatory markers based on acute phase glycoprotein signals (GlycA and GlycB) and sub-regions of the lipoprotein derived Supramolecular Phospholipid Composite signals (SPC1, SPC2 and SPC3) to establish normal ranges in two healthy, predominantly white cohorts from Australia (n = 398) and Spain (n = 80; ages 20-70 years). GlycA, GlycB, SPC1 and SPC3 were not significantly impacted by age or sex, but SPC2 (an HDL-related biomarker) was significantly higher in women across all age ranges by an average of 33.
View Article and Find Full Text PDFRole and modulation of various spinal pathways for human upper limb control in different gravity conditions.
PLoS Comput Biol
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Biorobotics Laboratory, EPFL, Lausanne, Switzerland.
Humans can perform movements in various physical environments and positions (corresponding to different experienced gravity), requiring the interaction of the musculoskeletal system, the neural system and the external environment. The neural system is itself comprised of several interactive components, from the brain mainly conducting motor planning, to the spinal cord (SC) implementing its own motor control centres through sensory reflexes. Nevertheless, it remains unclear whether similar movements in various environmental dynamics necessitate adapting modulation at the brain level, correcting modulation at the spinal level, or both.
View Article and Find Full Text PDFQuality of care offered by health care retail markets for medication abortion self-management: Findings from states in Nigeria and India.
PLOS Glob Public Health
January 2025
Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Dispensing of misoprostol and mifepristone by pharmacies and chemist shops for self-management of medication abortion (MA) fills a crucial gap in settings where abortion care by trained health professionals is not readily available. This promising service delivery pathway, endorsed by the World Health Organization (WHO), is hindered by concerns of poor-quality care. Simulated clients collected data on MA pill dispensing practices from 92 pharmacies and chemist shops in three Nigerian states and 127 pharmacies in an Indian state that we have anonymized.
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