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| http://dx.doi.org/10.1016/j.ultrasmedbio.2024.02.017 | DOI Listing |
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Synthetic gene circuits drive disease-fighting T cells.
Science
December 2024
Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, USA.
Immune cells can be programmed to deliver targeted therapies in models of brain and inflammatory disease.
View Article and Find Full Text PDFCommentary on the article titled "Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment-resistant depression following electroconvulsive therapy" by Xu et al.
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December 2024
Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia.
Tri-culture modeling of neuroinflammation, neurodegeneration, and neuroprotection.
J Alzheimers Dis
December 2024
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
The study of neurodegenerative diseases, such as Alzheimer's disease (AD), has long been a complex and challenging task. One of the major hurdles in understanding these diseases is the difficulty in recapitulating the complex interactions between neurons, astrocytes, and microglia in a laboratory setting. In recent years, researchers have made significant progress in developing triculture models that combine these three cell types, allowing for a more accurate representation of the cellular context of the human brain.
View Article and Find Full Text PDFKeep neuroinflammation in mind when addressing Alzheimer's disease: A microglia perspective.
J Alzheimers Dis
November 2024
Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
This commentary offers a detailed examination of a newly published paper on the effects of small molecule decoys of amyloid-β (Aβ) aggregation on microglial activation. It was discovered that the NSC16224 decoy peptide inhibited proinflammatory cytokines TNFα and IL6 release from microglia in response to Aβ and Aβ treatment. The research addresses the potential of blocking a sequence of events that lead to the progression of Alzheimer's disease (AD).
View Article and Find Full Text PDFExperimental West Nile virus infection provides lessons for recovery from enteric neuropathies.
J Clin Invest
November 2024
Loss of enteric neurons leading to long-term gastrointestinal dysfunction is common to many diseases, and the path to functional recovery is unclear. In this issue of the JCI, Janova et al. report that West Nile virus killed enteric neurons and glia via CD4+ and CD8+ T cells acting through the perforin and Fas ligand pathways.
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