AI Article Synopsis
- * Researchers performed DPD scans on 39 patients aged 70-85, finding that 7.7% had results indicating ATTR-CM, and these patients also showed significant left ventricular hypertrophy.
- * The findings suggest that doctors should consider ATTR-CM in older patients needing pacemakers, particularly if they have related conditions like spinal canal stenosis or carpal tunnel syndrome.
Article Abstract
Objective: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative cardiac disorder caused by deposition of wild type or mutated transthyretin. As ATTR-CM is associated with conduction disease, we sought to determine its prevalence in patients with idiopathic high-degree atrioventricular (AV) block requiring permanent pacemaker (PPM) implantation.
Methods: Consecutive patients aged 70-85 years undergoing PPM implantation for idiopathic high-degree AV block between November 2019 and November 2021 were offered a 3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan. Demographics, comorbidities, electrocardiographic and imaging data from the time of device implantation were retrospectively collected.
Results: 39 patients (79.5% male, mean (SD) age at device implantation 76.2 (2.9) years) had a DPD scan. 3/39 (7.7%, all male) had a result consistent with ATTR-CM (Perugini grade 2 or 3). Mean (SD) maximum wall thickness of those with a positive DPD scan was 19.0 mm (3.6 mm) vs 11.4 mm (2.7 mm) in those with a negative scan (p=0.06). All patients diagnosed with ATTR-CM had spinal canal stenosis and two had carpal tunnel syndrome.
Conclusions: ATTR-CM should be considered in older patients requiring permanent pacing for high-degree AV block, particularly in the presence of left ventricular hypertrophy, carpal tunnel syndrome or spinal canal stenosis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982802 | PMC |
| http://dx.doi.org/10.1136/openhrt-2024-002606 | DOI Listing |
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