AI Article Synopsis
- 212 Pb is a promising option for targeted α therapy due to its ideal half-life of 10.6 hours, suitable for small peptides.
- One major challenge with using 212 Pb is conducting accurate image-guided dosimetry, as existing data relies on its imaging counterpart, 203 Pb.
- This study reports the first human dosimetric estimates following a treatment cycle of 212 Pb VMT-α-peptide in a 41-year-old woman with advanced grade 2 neuroendocrine tumor, who showed a partial response.
Article Abstract
212 Pb emerges as a compelling in vivo α-particle generator for targeted α therapy due to its favorable half-life ( t1/2 = 10.6 hours) aligning with the biological half-lives of small peptides and its potent α-particle emissions within the decay series. However, one of the challenges with 212 Pb is to perform appropriate image-guided dosimetry. To date, all the data have been extrapolated from its imaging analog, 203 Pb. We present the first-in-human posttherapy image-guided dosimetric estimates of a single cycle of 212 Pb VMT-α-peptide, administered in a 41-year-old woman with an advanced grade 2 NET. The patient also demonstrated partial response on treatment.
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| http://dx.doi.org/10.1097/RLU.0000000000005190 | DOI Listing |
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