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Prediction Trough Concentrations of Valproic Acid Among Chinese Adult Patients with Epilepsy Using Machine Learning Techniques.
Pharm Res
January 2025
Department of Pharmacy, Jinshan Hospital Affiliated to Fudan University, Shanghai, China.
Objective: This study aimed to establish an optimal model based on machine learning (ML) to predict Valproic acid (VPA) trough concentrations in Chinese adult epilepsy patients.
Methods: A single-center retrospective study was carried out at the Jinshan Hospital affiliated with Fudan University from January 2022 to December 2023. A total of 102 VPA trough concentrations were split into a derivation cohort and a validation cohort at a ratio of 8:2.
Dietary Supplements for Weight Loss and Drug Interactions.
Pharmaceuticals (Basel)
December 2024
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
Food supplements are used for a variety of purposes, one of which is weight reduction. As excess weight is a long-term condition, some supplements are expected to be used for long periods of time. The long-term use of these dietary supplements makes it highly likely that they will be combined with medications, increasing the risk of food supplement-drug interactions, which are not always known or disclosed, and can lead to serious health problems, as has been observed.
View Article and Find Full Text PDFMonitoring of the trough concentration of valproic acid in pediatric epilepsy patients: a machine learning-based ensemble model.
Front Pharmacol
December 2024
Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Article Synopsis
- This study developed a machine learning ensemble model for monitoring valproic acid (VPA) in pediatric epilepsy patients to improve clinical accuracy in treatment.
- The model utilized data from 252 patients, using various algorithms like Gradient Boosting Regression Trees and Random Forest Regression, achieving high relative accuracy (87.8%) and low error rates.
- Key factors affecting VPA levels included platelet count and daily dose, indicating the model's potential to enhance clinical decision-making in VPA management.
Investigating Angiogenesis-Related Biomarkers in Osteoarthritis Patients Through Transcriptomic Profiling.
J Inflamm Res
December 2024
Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, People's Republic of China.
Background: Osteoarthritis (OA) is a common age-related joint disease characterized by joint destruction and impaired quality of life. Angiogenesis plays a vital role in OA progression. This study aimed to identify key angiogenesis-related genes (ARGs) in OA using transcriptomic and machine learning methods.
View Article and Find Full Text PDFConstruction of an animal model of autism based on interaction between cerebellar histological, immunohistochemical, and biochemical changes in adult male albino rat.
Ultrastruct Pathol
January 2025
Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Methods: Twelve pregnant female rats were divided into a control group and a valproic acid (VPA) treated group (injected intraperitoneally on embryonic day 12 with 600 mg/kg body weight of VPA). Neurobehavioral tests were conducted on the offspring of both groups. The cerebellum was studied by light and electron microscopy as well as GFAP and caspase-3 immunohistochemical staining.
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