AI Article Synopsis
- The study mapped the metabolite profiles of 34 isolates from 13 different species, identifying a total of 56 secondary metabolites produced by these organisms.
- Notably, only specific species were found to produce particular toxins, such as Pacific-ciguatoxins and maitotoxins, with ubiquitous production of 44-methylgambierone across all isolates.
- The findings suggest that while the isolates produce known ciguatoxins (CTXs) or maitotoxins (MTXs), they do not produce both, and point to the presence of uncharacterized compounds that warrant further investigation.
Article Abstract
The genus produces an array of bioactive hydrophilic and lipophilic secondary metabolites that range in mode of action and toxicity. In this study, the metabolite fingerprint was mapped for thirteen , five and two species (34 isolates) by assessing the production of 56 characterised secondary metabolites. was the only species to produce Pacific-ciguatoxin-3B (P-CTX3B), P-CTX3C, iso-P-CTX3B/C, P-CTX4A, P-CTX4B and iso-P-CTX4A/B. produced maitotoxin-1 (MTX-1) and MTX-5, produced MTX-6 and produced MTX-7. Ubiquitous production of 44-methylgambierone was observed amongst all the isolates, with nine species also producing gambierone. Additional gambierone analogues, including anhydrogambierone (tentatively described herein), were also detected in all species, two and two species. Gambieroxide was detected in and and gambieric acid A was detected in ten species, with (CAWD381) being the only isolate to produce gambieric acids A-D. This study has demonstrated that the isolates tested to date produce the known CTXs or MTXs, but not both, and highlighted several species that produced 'unknown' compounds displaying characteristics of cyclic polyethers, which will be the focus of future compound discovery efforts.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10972191 | PMC |
| http://dx.doi.org/10.3390/md22030119 | DOI Listing |
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