Two New Sesquiterpenoids and a New Shikimic Acid Metabolite from Mangrove Sediment-Derived Fungus sp. SCSIO 41427.

Two new sesquiterpenoid derivatives, elgonenes M () and N (), and a new shikimic acid metabolite, methyl 5--acetyl-5--shikimate (), were isolated from the mangrove sediment-derived fungus sp. SCSIO 41427 together with fourteen known compounds (-). The planar structures were elucidated through nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. The relative configurations of - were ascertained by NOESY experiments, while their absolute configurations were determined by electronic circular dichroism (ECD) calculation. Elgonene M () exhibited inhibition of interleukin-1β (IL-1β) mRNA, a pro-inflammatory cytokine, at a concentration of 5 μM, with an inhibitory ratio of 31.14%. On the other hand, elgonene N () demonstrated inhibition at a concentration of 20 μM, with inhibitory ratios of 27.57%.