AI Article Synopsis
- The placenta serves as a vital connection between the mother and developing fetus, offering protection, nutrient transport, and waste exchange.
- Some viruses possess the ability to invade the placenta, potentially causing harm like necrosis and complications for both the fetus and mother.
- Understanding these viral mechanisms can enhance research in maternal-fetal health and inform new therapeutic approaches and biomarkers for fetal development.
Article Abstract
In mammals, the placenta is a connection between a mother and a new developing organism. This tissue has a protective function against some microorganisms, transports nutrients, and exchanges gases and excretory substances between the mother and the fetus. Placental tissue is mainly composed of chorionic villi functional units called trophoblasts (cytotrophoblasts, the syncytiotrophoblast, and extravillous trophoblasts). However, some viruses have developed mechanisms that help them invade the placenta, causing various conditions such as necrosis, poor perfusion, and membrane rupture which, in turn, can impact the development of the fetus and put the mother's health at risk. In this study, we collected the most relevant information about viral infection during pregnancy which can affect both the mother and the fetus, leading to an increase in the probability of vertical transmission. Knowing these mechanisms could be relevant for new research in the maternal-fetal context and may provide options for new therapeutic targets and biomarkers in fetal prognosis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969698 | PMC |
| http://dx.doi.org/10.3390/diseases12030059 | DOI Listing |
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