The importance of fungal infections, particularly those caused by yeasts, is increasing among the medical community. and are amongst the high-priority fungal species identified by the World Health Organization (WHO) and are considered in the critical group, while is included in the medium-priority group. The cyclam salt H[H(PhCH)Cyclam]Cl proved to be active against the growth of these three yeasts, and the aim of this work was to verify its interference with their virulence mechanisms, whether shared or unique. H[H(PhCH)Cyclam]Cl significantly inhibited biofilm production and catalase activity, being able to interfere with dimorphic transition and melanin production. At the minimal inhibitory concentration (MIC) values, H[H(PhCH)Cyclam]Cl had no antioxidant effect, as determined by the DPPH method. When using the RAW264.7 macrophage cell line, H[H(PhCH)Cyclam]Cl reduced nitric oxide (NO) detection (the Griess reaction), but this effect was associated with a significant toxic effect on the cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10967529 | PMC |
| http://dx.doi.org/10.3390/antibiotics13030222 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Disclosing the Antifungal Mechanisms of the Cyclam Salt H[H(PhCH)Cyclam]Cl against and .
Int J Mol Sci
May 2024
Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto.CCC), 4169-007 Porto, Portugal.
Mycoses are one of the major causes of morbidity/mortality among immunocompromised individuals. Considering the importance of these infections, the World Health Organization (WHO) defined a priority list of fungi for health in 2022 that include as belonging to the critical priority group and () to the medium priority group. The existence of few available antifungal drugs, their high toxicity, the acquired fungal resistance, and the appearance of new species with a broader spectrum of resistance, points out the need for searching for new antifungals, preferably with new and multiple mechanisms of action.
View Article and Find Full Text PDFA Cyclam Salt as an Antifungal Agent: Interference with spp. and Mechanisms of Virulence.
Antibiotics (Basel)
February 2024
Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy, University of Porto (UP), Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
The importance of fungal infections, particularly those caused by yeasts, is increasing among the medical community. and are amongst the high-priority fungal species identified by the World Health Organization (WHO) and are considered in the critical group, while is included in the medium-priority group. The cyclam salt H[H(PhCH)Cyclam]Cl proved to be active against the growth of these three yeasts, and the aim of this work was to verify its interference with their virulence mechanisms, whether shared or unique.
View Article and Find Full Text PDFPorous Salts as Platforms for Heterogeneous Catalysis.
Small
July 2023
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.
The preparation of a new class of reactive porous solids, prepared via straightforward salt metathesis reactions, is described here. Reaction of the dimethylammonium salt of a magnesium-based porous coordination cage with the chloride salt of [Cr Cl(Me cyclam)] affords a porous solid with concomitant removal of dimethylammonium chloride. The salt consists of the ions combined in the expected ratio based on their charge as confirmed by UV-vis and X-ray photoelectron spectroscopies, ion chromatography (IC), and inductively coupled plasma mass spectrometry (ICP-MS).
View Article and Find Full Text PDFSynthesis and crystal structure of poly[[di-μ-tetra-thio-anti-monato-tris-[(cyclam)cobalt(II)]] aceto-nitrile disolvate dihydrate] (cyclam = 1,4,8,11-tetra-aza-cyclo-tetra-deca-ne).
Acta Crystallogr E Crystallogr Commun
February 2022
Institut für Anorganische Chemie, Universität Kiel, Max-Eyth.-Str. 2, D-24118 Kiel, Germany.
Reaction of Co(ClO)·6HO with cyclam (cyclam = 1,4,8,11-tetra-aza-cyclo-tetra-deca-ne) and NaSbS·9HO (Schlippesches salt) in a mixture of aceto-nitrile and water leads to the formation of crystals of the title compound with the composition {[Co(SbS)(CHN)]·2CHCN·2HO} or {[(Co-cyclam)(SbS)]·2(aceto-nitrile)·2HO} . The crystal structure of the title compound consists of three crystallographically independent [Co-cyclam] cations, which are located on centers of inversion, one [SbS] anion, one water and one aceto-nitrile mol-ecule that occupy general positions. The aceto-nitrile mol-ecule is disordered over two orientations and was refined using a split model.
View Article and Find Full Text PDFSpectroscopic study of cyclen-based F NMR probe for detection of hydrogen sulfide.
Anal Sci
May 2022
Department of Analytical Chemistry, Kyoto Pharmaceutical University, 5 Misasaginakauchi-cho, Yamashina-ku, Kyoto, 607-8414, Japan.
A cyclen-based F NMR probe (F-cyclen) for hydrogen sulfide (HS) has been prepared and evaluated for its complex formation ability with Cu ions and responsivity to HS. F-Cyclen was readily synthesized by reacting cyclen with 4-(trifluoromethyl)benzyl bromide. Visible absorption spectrophotometry showed that, same as the original cyclen, F-cyclen formed a 1:1 complex with Cu ions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!