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Copper complexes induce haem oxygenase-1 (HMOX1) and cause apoptotic cell death in pancreatic cancer cells.
J Inorg Biochem
December 2024
Division of Pharmacology, Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa. Electronic address:
Pancreatic ductal adenocarcinoma (PDAC), the most common pancreatic malignancy, has a dismal 5-year survival rate, making palliative chemotherapy the only treatment option. Targeted therapy has limited efficacy in PDAC, underscoring the need for novel therapeutic approaches. The inducible stress-response protein, haem oxygenase-1 (HMOX1), has been implicated in treatment failure in PDAC.
View Article and Find Full Text PDFLooking at the albumin-drug binding via partitioning in aqueous two-phase system.
Biochem Biophys Res Commun
December 2024
Cleveland Diagnostics, 3615 Superior Ave., Cleveland, OH, 44114, USA. Electronic address:
The partition coefficient of human serum albumin (HSA) was analyzed in the PEG600-Dex70, 0.15 M NaCl/KCl in 0.01 M Na/K phosphate buffer, pH 7.
View Article and Find Full Text PDFOptimization of physicochemical properties of theophylline by forming cocrystals with amino acids.
RSC Adv
December 2024
Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 P.R. China
This study presents the synthesis and characterization of novel cocrystal structures of theophylline (THE) with the amino acids gamma-aminobutyric acid (GABA) and l-arginine (ARG). Despite a large number of reports about THE cocrystals, no crystallographic parameters of cocrystals formed by THE and amino acids have been reported. THE is characterized by low solubility, while amino acids as cocrystal co-formers (CCFs) are increasingly recognized for their high solubility and safety.
View Article and Find Full Text PDFTheophylline alleviates cyclophosphamide-induced T cell senescence by downregulating acetylation of p53 at lysine 373.
Int Immunopharmacol
December 2024
Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China. Electronic address:
Cyclophosphamide is a widely used immunosuppressive and chemotherapeutic agent in clinics. Previous studies have indicated that cyclophosphamide treatment induces cellular senescence in patients, although the underlying mechanisms remain elusive. Here, we reported that cyclophosphamide induced T cell senescence in the spleen of mice.
View Article and Find Full Text PDFSynthesis of photo-responsive κ-carrageenan-based hydrogels for drug delivery application.
Int J Biol Macromol
December 2024
Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Natural polymer-based hydrogels may act as versatile platforms in controlled drug delivery. In this regard, photoactive κ-carrageenan (κ-Crg) hydrogels modified with cinnamate (CN) groups are developed for pH-sensitive release of drugs. κ-Crg-CN derivatives containing 17 %, 33 %, and 49 % cinnamate contents, named κ-Crg-CN1, κ-Crg-CN2, and κ-Crg-CN3, respectively, are prepared and cross-linked by UV-induced [2π + 2π] cycloaddition.
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