Quantitative differentiation of non-invasive bladder urothelial carcinoma and inverted papilloma based on CT urography.

BMC Urol

Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 1# Banshan East Road, Hangzhou, 310022, China.

Published: March 2024

AI Article Synopsis

  • The study examines the effectiveness of CT urography (CTU) indicators in distinguishing between bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB).
  • A total of 103 patients' CTU data were analyzed for qualitative and quantitative indicators, leading to the development of a predictive model that helps in diagnosis.
  • Key indicators such as junction smoothness, maximum tumor diameter, tumor-wall interface, and arterial reinforcement rate were found to significantly differentiate BUC from IPB, resulting in a high diagnostic accuracy of the combined model (AUC = 0.934).

Article Abstract

Purpose: To investigate the value of CT urography (CTU) indicators in the quantitative differential diagnosis of bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB).

Material And Methods: The clinical and preoperative CTU imaging data of continuous 103 patients with histologically confirmed BUC or IPB were retrospectively analyzed. The imaging data included 6 qualitative indicators and 7 quantitative measures. The recorded clinical information and imaging features were subjected to univariate and multivariate logistic regression analysis to find independent risk factors for BUC, and a combined multi-indicator prediction model was constructed, and the prediction model was visualized using nomogram. ROC curve analysis was used to calculate and compare the predictive efficacy of independent risk factors and nomogram.

Results: Junction smoothness, maximum longitudinal diameter, tumor-wall interface and arterial reinforcement rate were independent risk factors for distinguishing BUC from IPB. The AUC of the combined model was 0.934 (sensitivity = 0.808, specificity = 0.920, accuracy = 0.835), and its diagnostic efficiency was higher than that of junction smoothness (AUC=0.667, sensitivity = 0.654, specificity = 0.680, accuracy = 0.660), maximum longitudinal diameter (AUC=0.757, sensitivity = 0.833, specificity = 0.604, accuracy = 0.786), tumor-wall interface (AUC=0.888, sensitivity = 0.755, specificity = 0.808, accuracy = 0.816) and Arterial reinforcement rate (AUC=0.786, sensitivity = 0.936, specificity = 0.640, accuracy = 0.864).

Conclusion: Above qualitative and quantitative indicators based on CTU and the combination of them may be helpful to the differential diagnosis of BUC and IPB, thus better assisting in clinical decision-making.

Key Points: 1. Bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB) exhibit similar clinical symptoms and imaging presentations. 2. The diagnostic value of CT urography (CTU) in distinguishing between BUC and IPB has not been documented. 3. BUC and IPB differ in lesion size, growth pattern and blood supply. 4. The diagnostic efficiency is optimized by integrating multiple independent risk factors into the prediction model.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964599PMC
http://dx.doi.org/10.1186/s12894-024-01459-yDOI Listing

Publication Analysis

Top Keywords

buc ipb
20
independent risk
16
risk factors
16
bladder urothelial
12
urothelial carcinoma
12
inverted papilloma
12
prediction model
12
urography ctu
8
indicators quantitative
8
differential diagnosis
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!