Formaldehyde is commonly thought of as an environmental toxin or laboratory fixation reagent, but there is a growing appreciation for its broader physiological contributions as a naturally generated one-carbon metabolite across all kingdoms of life. In this In Focus article, we summarize emerging advances in the field that show how formaldehyde plays diverse roles as a one-carbon signal in DNA damage, one-carbon metabolism, and epigenetic regulation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495415 | PMC |
http://dx.doi.org/10.1021/acschembio.4c00106 | DOI Listing |
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