The fitness level method is a popular tool for analyzing the hitting time of elitist evolutionary algorithms. Its idea is to divide the search space into multiple fitness levels and estimate lower and upper bounds on the hitting time using transition probabilities between fitness levels. However, the lower bound generated by this method is often loose. An open question regarding the fitness level method is what are the tightest lower and upper time bounds that can be constructed based on transition probabilities between fitness levels. To answer this question, we combine drift analysis with fitness levels and define the tightest bound problem as a constrained multi-objective optimization problem subject to fitness levels. The tightest metric bounds by fitness levels are constructed and proven for the first time. Then linear bounds are derived from metric bounds and a framework is established that can be used to develop different fitness level methods for different types of linear bounds. The framework is generic and promising, as it can be used to draw tight time bounds on both fitness landscapes with and without shortcuts. This is demonstrated in the example of the (1+1) EA maximizing the TwoMax1 function.
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Sci Rep
December 2024
Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, Henan Province, China.
This study aimed to assess its relationship between physical activity with health-related indicators in older population of the China. Cross-sectional data of 1,327 individuals aged 60-79 years were analyzed. Based on the Fifth National Physical Fitness Monitoring Program, depressive symptom and loneliness were measured using the Patient Health Questionnaire-9 and Emotional versus Social Loneliness Scales, respectively.
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December 2024
Departamento de Cirugía, Ciencias Médicas y Sociales, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Spain.
Previous research has focused on the possibility of cervical dysfunction in migraine patients, similar to what is observed in patients with tension-type headaches. However, there is no evidence concerning the physical function of other body regions, even though lower levels of physical activity have been reported among migraine patients. The aim of this study was to compare cervical and extra-cervical range of motion, muscular strength, and endurance, as well as overall levels of physical activity, between patients with chronic migraine (CM) and asymptomatic participants.
View Article and Find Full Text PDFCancer Genomics Proteomics
December 2024
Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
Background/aim: Treatment with retinoic acid (RA) often promotes neuroblastoma differentiation and growth inhibition, including the suppression of the expression of the MYCN oncogene. However, RA also targets protumoral chemokines, such as CCL2, which may contribute to the development of resistance. The present study aimed to investigate the regulation and function of CCL2 and N-Myc in RA-treated neuroblastoma cells.
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
School of Life Sciences, Xiangya School of Medicine, Central South University, Changsha 510006, China. Electronic address:
Diisooctyl phthalate (DIOP), a common phthalate plasticizer, is frequently encountered in everyday life. Despite its widespread use, there is a dearth of toxicological research on DIOP, resulting in incomplete knowledge of its potential harmful effects. Our current research endeavored to provide a comprehensive evaluation of DIOP's toxicological profile using both cellular and Caenorhabditis elegans models as our in vitro and in vivo study subjects.
View Article and Find Full Text PDFContemp Nurse
December 2024
Department of Rehabilitation Science, Clinic for Rehabilitation Muenster, Groeben 700, Muenster 6232, Austria.
Background: The number of patients with neurological disorders and severe disability is increasing globally. These patients often need help with positioning and the amount of support varies with their level of impairment. High rates of work-related musculoskeletal disorders are observed among healthcare professionals (HCP) with patient contact due to injuries during manual handling.
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