AI Article Synopsis
- The study evaluates the CUBN/MPO ratio as a possible biomarker for aggressive T1 bladder cancer, aiming to improve early intervention and patient survival.
- Urine samples from 30 patients with high-grade T1 bladder cancer were analyzed, revealing that those with a low CUBN/MPO ratio had a higher risk of cancer recurrence and progression.
- The findings suggest the CUBN/MPO ratio could be a valuable prognostic tool; however, additional research on larger samples is needed to confirm these results.
Article Abstract
Purpose: T1 bladder cancer is known for its high progression and recurrence rates. Identifying aggressive tumours at the non-muscle-invasive stage is crucial to allow early interventions and subsequently increase patient survival. This study aimed to investigate the potential of the cubilin/myeloperoxidase (CUBN/MPO) ratio as a high-grade T1 bladder cancer biomarker.
Methods: Urine samples were collected from 30 patients who underwent transurethral resection of the tumour with high-grade T1 bladder cancer (June 2015 to December 2019) before surgery. The urinary proteome was analysed using high-resolution mass spectrometry and the CUBN/MPO ratio was calculated. The primary outcome was the recurrence during the follow-up (around 31.5 months after resection). Univariate Cox regression and Kaplan-Meier curves were used for data analysis.
Results: Patients with a low CUBN/MPO ratio exhibited upregulated MPO and/or downregulated CUBN. This group of patients had a higher incidence of disease recurrence and progression. Low CUBN/MPO ratio was significantly associated with a higher likelihood of recurrence, progression, and death. It is worth noting that this study was exploratory and conducted on a small sample size, so further research is needed to validate these findings in larger cohorts.
Conclusion: This study highlights the potential of the CUBN/MPO ratio as a prognostic biomarker for high-grade T1 bladder cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266244 | PMC |
| http://dx.doi.org/10.1007/s11255-024-03971-4 | DOI Listing |
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