Synthesis of -fused cyclopentenone-pyrrolidine scaffolds sequential aza-Piancatelli and Conia-ene type reactions in one pot.

A novel one-pot protocol that enables sequential execution of an aza-Piancatelli rearrangement and a Conia-ene type reaction has been developed under Lewis acid catalysis. Here, a combination of B(CF) and Cu(OTf), triethylamine, and triphenylphosphine yielded a wide range of -fused cyclopentenone-pyrrolidine scaffolds in one pot with good yields and diastereoselectivity.