Background: This single-center retrospective study evaluated early failure rates for an unicompartmental knee arthroplasty (UKA) system with an anti-allergic surface.
Methods: We studied 87 consecutive joints received an UKA at a single center between 2017 and 2020. All patients received a fully cemented anti-allergic Univation-Aesculap partial knee replacement implant with a corundum blasting surface. All joints had precise indication of unicompartmental arthroplasty according to the current criteria of this procedure. The current series was restricted to patients undergoing medial cemented UKA. Medial compartment osteoarthritis was the main indication.
Results: We found early failure (aseptic loosening) was documented in 20 of the 87 joints (23%). The time to failure ranged from 7 weeks to 3 years, for an estimated 33% (15-46%) cumulative hazard rate for implant loosening over three years. No cases of periprosthetic joint infection were found. On average, the patients began complaining about first symptoms during the third month after surgery. In most cases (66.66%), the cement remained fixed to the bone.
Conclusions: Based on these early results, the manufacturer of this implant stopped all further distribution. Continued efforts should be made to understand the clinical and radiographic outcomes of alternative and anti-allergic surface coatings in knee arthroplasty.
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http://dx.doi.org/10.21037/aoj-22-18 | DOI Listing |
Med Educ Online
December 2025
Imperial College School of Medicine, Imperial College London, London, UK.
Resitting, being offered a 'second chance' at an exam following failure to achieve a passing grade, is both common and stressful in medical school. There is a significant gap in the medical education literature around evidence-based support for resitting medical students. The study explores medical student experiences of resits through a peer-assisted learning programme (PAL) delivered to early years resitting medical students at Imperial College School of Medicine (ICSM) in 2021 and 2022.
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March 2025
National Amyloidosis Centre, University College London, Royal Free Hospital, London, United Kingdom.
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed chronic disease associated with progressive heart failure that results in impaired quality of life, repeated hospitalizations, and premature death. Acoramidis is a selective, oral transthyretin stabilizer recently approved by the U.S.
View Article and Find Full Text PDFDaru
March 2025
Thoracic Research Center, Imam Khomeini, Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: Leukocytoclastic vasculitis (LCV) is a small-vessel inflammatory condition that can rarely occur as an adverse drug reaction (ADR). Vancomycin-induced LCV is an uncommon but potentially serious complication, particularly in patients with pre-existing renal impairment.
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Cells
March 2025
School of Clinical Medicine, Tsinghua University, Beijing 100190, China.
Sepsis is a complex clinical syndrome closely associated with the occurrence of acute organ dysfunction and is often characterized by high mortality. Due to the rapid progression of sepsis, early diagnosis and intervention are crucial. Recent research has focused on exploring the pathological response involved in the process of sepsis.
View Article and Find Full Text PDFThis paper systematically reviews literature to date about how child welfare workers' decisions about neglect are influenced by their environments. We conducted a systematic search of Web of Science, Embase, PsycInfo, Scopus, and Applied Social Sciences Index & Abstracts, looking for studies in English of any methodology, published since the 1989 Children Act, in which statutory thresholds in England are defined. We used child welfare workers' definitions of neglect or, in the absence of this, defined "neglect" as harmful acts of omission by a caregiver (failure to do something necessary for a child's well-being).
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