AI Article Synopsis
- Dendritic cells (DCs) play a significant role in the inflammatory response following spinal cord injury (SCI), affecting T lymphocyte differentiation and releasing supportive cytokines.
- The review explores how DCs can activate other immune cells and promote healing, leading to better recovery outcomes.
- Highlighting their repair mechanisms, the study suggests that targeting DCs could offer new therapeutic strategies for treating SCI.
Article Abstract
Background: Inflammation can worsen spinal cord injury (SCI), with dendritic cells (DCs) playing a crucial role in the inflammatory response. They mediate T lymphocyte differentiation, activate microglia, and release cytokines like NT-3. Moreover, DCs can promote neural stem cell survival and guide them toward neuron differentiation, positively impacting SCI outcomes.
Objective: This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI.
Methods: Literature in PubMed and Web of Science was reviewed using critical terms related to DCs and SCI.
Results: The study indicates that DCs can activate microglia and astrocytes, promote T-cell differentiation, increase neurotrophin release at the injury site, and subsequently reduce secondary brain injury and enhance functional recovery in the spinal cord.
Conclusions: This review highlights the repair mechanisms of DCs and their potential therapeutic potential for SCI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964036 | PMC |
| http://dx.doi.org/10.1111/cns.14593 | DOI Listing |
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