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Prevalence and prenatal diagnosis of congenital eye anomalies: A population-based study. | LitMetric

AI Article Synopsis

  • The study aimed to estimate the prevalence and trends of congenital eye anomalies (CEAs) in Paris from 2010 to 2020, analyzing data from all maternity units in the area.
  • Out of 115 identified cases of CEAs, the overall prevalence was 4.1 cases per 10,000 births, with 23.5% being prenatally diagnosed.
  • It was found that CEAs were commonly associated with other anomalies, as 20.9% had genetic issues, and 53% had additional extraocular anomalies, with a lower prenatal detection rate for isolated CEAs at only 13.3%.

Article Abstract

Objective: To estimate the prevalence and trend of congenital eye anomalies (CEAs) and the rate of prenatal diagnosis over a 10-year period.

Design: Retrospective population-based registry study.

Setting: All maternity units in Paris, France, from 2010 to 2020.

Population: A cohort of 115 cases of CEA detected among all live births or stillbirths, after 22 weeks of gestation, and terminations of pregnancy.

Methods: The total prevalence of CEAs and prevalence of each specific CEA were calculated using 95% Poisson exact confidence intervals.

Main Outcome Measures: The total prevalence of CEAs and the proportion of prenatal diagnosis of CEAs, and their evolution.

Results: The prevalence of CEAs was 4.1 (95% CI 3.4-5.0) cases, ranging between 3.1 and 5.7 cases, per 10 000 births. CEAs were prenatally diagnosed in 23.5% of cases. CEAs were bilateral in 51 cases (44.3%), unilateral in 43 cases (37.4%) and missing or unknown in 21 cases (18.3%). Of those with CEAs, 20.9% had genetic anomalies and 53.0% had at least one other extraocular anomaly. When detected prenatally, CEAs were bilateral in 15 cases (55.6%), unilateral in eight cases (29.6%) and missing in the four remaining cases. The prenatal diagnosis rate of CEAs associated with genetic anomalies, CEA cases with at least one other malformation and isolated CEA cases were 29.2%, 26.2% and 13.3%, respectively.

Conclusions: In total, 115 cases of CEAs were observed during the study period, representing a total prevalence of 4.1 cases per 10 000 births. The overall prenatal detection rate of CEAs in our population was 23.5%, which dropped to 13.3% for isolated cases of CEAs.

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Source
http://dx.doi.org/10.1111/1471-0528.17817DOI Listing

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