Glutamicibacter nicotianae AT6: A new strain for the efficient biodegradation of tilmicosin.

J Environ Sci (China)

College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China; College of Chemistry and Chemical Engineering, Heze University, Heze 274015, China. Electronic address:

Published: August 2024

The degradation of tilmicosin (TLM), a semi-synthetic 16-membered macrolide antibiotic, has been receiving increasing attention. Conventionally, there are three tilmicosin degradation methods, and among them microbial degradation is considered the best due to its high efficiency, eco-friendliness, and low cost. Coincidently, we found a new strain, Glutamicibacter nicotianae sp. AT6, capable of degrading high-concentration TLM at 100 mg/L with a 97% removal efficiency. The role of tryptone was as well investigated, and the results revealed that the loading of tryptone had a significant influence on TLM removals. The toxicity assessment indicated that strain AT6 could efficiently convert TLM into less-toxic substances. Based on the identified intermediates, the degradation of TLM by AT6 processing through two distinct pathways was then proposed.

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Source
http://dx.doi.org/10.1016/j.jes.2023.07.009DOI Listing

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