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Machine learning prediction of hepatic encephalopathy for long-term survival after transjugular intrahepatic portosystemic shunt in acute variceal bleeding.
World J Gastroenterol
January 2025
Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510151, Guangdong Province, China.
Background: Transjugular intrahepatic portosystemic shunt (TIPS) is an effective intervention for managing complications of portal hypertension, particularly acute variceal bleeding (AVB). While effective in reducing portal pressure and preventing rebleeding, TIPS is associated with a considerable risk of overt hepatic encephalopathy (OHE), a complication that significantly elevates mortality rates.
Aim: To develop a machine learning (ML) model to predict OHE occurrence post-TIPS in patients with AVB using a 5-year dataset.
Value of systemic inflammation markers for the detection of minimal and prediction of overt hepatic encephalopathy after TIPS insertion.
Metab Brain Dis
December 2024
Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Development of overt hepatic encephalopathy (oHE) is a particularly feared complication when considering treatment with transjugular intrahepatic portosystemic shunt (TIPS). However, the pathophysiology of HE, in particular after TIPS-insertion, is complex and valid predictors remain scarce. We aimed to investigate whether systemic inflammation markers (SIM) are linked to minimal (mHE) and overt HE (oHE) development before and after TIPS.
View Article and Find Full Text PDFAnalysis of independent risk factors for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis combined with diabetes.
Eur J Gastroenterol Hepatol
February 2025
Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College, Nanjing Medical University.
Objective: This study aimed to reveal the independent risk factors for overt hepatic encephalopathy (OHE) after transjugular intrahepatic portosystemic shunt (TIPS) in patients with decompensated cirrhosis complicated with diabetes.
Patients And Methods: This study retrospectively analyzed 126 consecutive patients with cirrhosis combined with diabetes who underwent TIPS in our department from January 2016 to June 2022. The patients were divided into two groups according to the presence or absence of OHE after TIPS.
Identifying the optimal measurement timing and hemodynamic targets of portal pressure gradient after TIPS in patients with cirrhosis and variceal bleeding.
J Hepatol
February 2025
Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Centre for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China; Department of Liver Diseases and Digestive Interventional Radiology, Digestive Diseases Hospital, Xi'an International Medical Center Hospital, Northwest University, Xi'an 710032, China. Electronic address:
Article Synopsis
- The study investigates the best timing and target for measuring portacaval pressure gradient (PPG) in patients who have undergone transjugular intrahepatic portosystemic shunt (TIPS) for variceal bleeding.
- Researchers analyzed data from 466 patients, measuring PPG at three time points: immediately after, 24-72 hours post, and one month after TIPS placement.
- Findings indicate that PPG measured 24-72 hours after TIPS is more predictive of long-term outcomes, with an optimal target range of 11-14 mmHg linked to reduced risk of complications like hepatic encephalopathy.
Spleen volume is associated with overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with portal hypertension.
World J Gastrointest Surg
July 2024
College of Medical Imaging, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
Article Synopsis
- The study aims to assess the connection between spleen volume and the onset of hepatic encephalopathy (HE) following transjugular intrahepatic portosystemic shunt (TIPS) in patients with liver cirrhosis.
- It analyzed data from 135 patients, revealing that a smaller spleen volume post-TIPS was significantly linked to a higher incidence of overt HE, with 37 patients (27.2%) experiencing it within a year.
- The findings suggest that preoperative spleen volume serves as an independent risk factor for developing HE after the TIPS procedure, indicating its importance in patient monitoring and management.
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