Syphilis is an important global health threat and little has changed in its treatment since the mid-20th century. For late-latent or syphilis infection of unknown duration, the standard treatment of multiple intramuscular injections of benzathine penicillin G (BPG) are associated with significant pain and distress to clients and caregivers, negatively impacting on treatment completion. Based on pharmacokinetic modelling from a Phase I study of subcutaneous infusion of high dose BPG (SCIP), we present its feasibility, safety and tolerability for treatment of syphilis in a single infusion. SCIP leads to more sustained penicillin concentrations above the desired target with less reported pain and reduced clinic visits.
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Article Synopsis
- The study aims to assess syphilis treatment and prenatal care during pregnancy to find ways to prevent congenital syphilis.
- It involved enhanced surveillance across six jurisdictions and analyzed data on syphilis treatment adequacy and prenatal care timing among 1,476 pregnant individuals with syphilis.
- Results showed 42.1% received inadequate treatment, with timely prenatal care linked to better outcomes, although 32.1% of those with timely care still received inadequate treatment, highlighting significant gaps in care, especially for those with substance use or homelessness issues.
Could late-latent syphilis be treated with a single subcutaneous infusion of long-acting penicillin?
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Syphilis is an important global health threat and little has changed in its treatment since the mid-20th century. For late-latent or syphilis infection of unknown duration, the standard treatment of multiple intramuscular injections of benzathine penicillin G (BPG) are associated with significant pain and distress to clients and caregivers, negatively impacting on treatment completion. Based on pharmacokinetic modelling from a Phase I study of subcutaneous infusion of high dose BPG (SCIP), we present its feasibility, safety and tolerability for treatment of syphilis in a single infusion.
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