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Detection of Debonding Defects in Concrete-Filled Steel Tubes Using Fluctuation Analysis Method.
Sensors (Basel)
December 2024
College of Civil Engineering and Architecture, Xiamen University of Technology, Xiamen 361024, China.
This study presents a comprehensive method for detecting debonding defects in concrete-filled steel tube (CFST) structures using wave propagation analysis with externally attached piezoelectric ceramic sensors. Experimental tests and numerical simulations were conducted to evaluate the sensitivity and accuracy of two measurement techniques-the flat and oblique measurement methods-in detecting debonding defects of varying lengths and heights. The results demonstrate that the flat measurement method excels in detecting debonding height, while the oblique method is more effective for detecting debonding length.
View Article and Find Full Text PDFAccelerated Aging Effect on the Stability of the 3D-Printed Biodegradable Implant for Bone Defect Repairs.
Materials (Basel)
December 2024
Institute of Security Technologies "MORATEX", 3 Marii Sklodowskiej-Curie Str., 90-505 Lodz, Poland.
This article presents an evaluation of the accelerated aging impact on the structural properties of biodegradable PLA/HAp implants produced using 3D printing technology for use in traumatic bone defect repairs in individual patients. The designed biodegradable implants were sterilized with a radiation dose of 25 ± 0.99% kGy, then exposed to an accelerated aging process.
View Article and Find Full Text PDFAging-Related Gene-Based Prognostic Model for Lung Adenocarcinoma: Insights into Tumor Microenvironment and Therapeutic Implications.
Int J Mol Sci
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Department of Toxicology, School of Public Health, Suzhou Medicine College of Soochow University, Suzhou 215123, China.
Lung cancer remains the leading cause of cancer-related mortality globally, with a poor prognosis primarily due to late diagnosis and limited treatment options. This research highlights the critical demand for advanced prognostic tools by creating a model centered on aging-related genes (ARGs) to improve prediction and treatment strategies for lung adenocarcinoma (LUAD). By leveraging datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), we developed a prognostic model that integrates 14 ARGs using the least absolute shrinkage and selection operator (LASSO) alongside Cox regression analyses.
View Article and Find Full Text PDFLAP1 Interactome Profiling Provides New Insights into LAP1's Physiological Functions.
Int J Mol Sci
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Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.
The nuclear envelope (NE), a protective membrane bordering the nucleus, is composed of highly specialized proteins that are indispensable for normal cellular activity. Lamina-associated polypeptide 1 (LAP1) is a NE protein whose functions are just beginning to be unveiled. The fact that mutations causing LAP1 deficiency are extremely rare and pathogenic is indicative of its paramount importance to preserving human health, anticipating that LAP1 might have a multifaceted role in the cell.
View Article and Find Full Text PDFTemporal Tissue Remodeling in Volumetric Muscle Injury with Endothelial Cell-Laden Patterned Nanofibrillar Constructs.
Bioengineering (Basel)
December 2024
Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.
A primary challenge following severe musculoskeletal trauma is incomplete muscle regeneration. Current therapies often fail to heal damaged muscle due to dysregulated healing programs and insufficient revascularization early in the repair process. There is a limited understanding of the temporal changes that occur during the early stages of muscle remodeling in response to engineered therapies.
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