Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/IIO.0000000000000487 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Levofloxacin-loaded silicone contact lenses materials for ocular drug delivery.
J Biomater Appl
December 2024
College of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
Silicone contact lenses (SCL), as an emerging ocular drug delivery system, achieve controlled drug release. However, the existing drug loading methods have limitations such as low drug uptake, complicated operation process, poor welling rate and transmittance of the lens after drug loading. In this study, an effective microemulsion soaking method was proposed to increase the drug-loading capacity of silicone contact lenses.
View Article and Find Full Text PDFSuprachoroidal delivery of viral and non-viral vectors for treatment of retinal and choroidal vascular diseases.
Am J Ophthalmol
December 2024
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University, Baltimore, MD; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Chemical & Biomolecular Engineering and Materials Science & Engineering, Johns Hopkins University, Baltimore, MD; Departments of Neurosurgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD. Electronic address:
Current treatments for retinal and choroidal neovascular diseases suffer from insufficient durability, including anti-vascular endothelial growth factor-A (VEGF-A) agents. It is, therefore, of interest to explore alternative methods that could allow for robust improvement in visual acuity with fewer injections required. Amongst various pre-clinical and clinical studies in the literature, a promising approach is the use of suprachoroidal injection with viral and non-viral gene delivery vectors.
View Article and Find Full Text PDFRetinal thickness predicts the risk of cognitive decline over five years.
Alzheimers Res Ther
December 2024
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Background: Dementia poses a significant burden on healthcare systems. Early identification of individuals at risk for cognitive decline is crucial. The retina, an extension of the central nervous system, reflects neurodegenerative changes.
View Article and Find Full Text PDFDevelopment of axitinib-loaded polymeric ocular implants for the treatment of posterior ocular diseases.
Int J Pharm
December 2024
School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom. Electronic address:
Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are the primary causes of vision impairment and blindness worldwide. The current treatment for these diseases is an intravitreal injection of anti-VEGF agents, which are costly and require frequent injections. Implants can be used to sustain the release of drugs and minimize side effects.
View Article and Find Full Text PDFretinal melanin detection with the calibrated depolarization index in polarization-sensitive optical coherence tomography.
J Biomed Opt
December 2024
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Significance: A data-based calibration method with enhanced depolarization contrast in polarization-sensitive optical coherence tomography (PS-OCT) was developed and demonstrated effective for detecting melanin content in the eye.
Aim: We aim to mitigate the dependence between the measured depolarization metric and the intensity signal-to-noise ratio (SNR) for improved visualization of depolarizing tissues, especially in low SNR regions, and to demonstrate the enhanced depolarization contrast to evaluate melanin presence.
Approach: A function for calibrating the depolarization metric was experimentally derived from the young albino guinea pig, assuming depolarization free in the retina.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!