AI Article Synopsis
- Age-associated B cells (ABCs) are a type of memory B cell that emerge during infections and autoimmune diseases, yet their development process is not fully understood.
- A study by Dai et al. identifies ZEB2 as a crucial transcription factor that helps specify the ABC lineage by suppressing other potential differentiative pathways and promoting genes essential for their function.
- The findings suggest a strong connection between the fate of ABCs and their role in autoimmune disorders, indicating that understanding ZEB2's function could lead to insights into these diseases.
Article Abstract
Age-associated B cells (ABCs) are a stable subset of memory B lymphocytes that develop during microbial infections and in autoimmune diseases. Despite growing appreciation of their phenotypic and functional characteristics, the transcriptional networks involved in ABC fate commitment and maintenance have remained elusive. In their recent publication, Dai et al. tackle this problem, leveraging both mouse models and human diseases to reveal zinc finger E-box-binding homeobox 2 (ZEB2) as a key transcriptional regulator of ABC lineage specification. In aggregate, their results show that ZEB2, a member of the zinc finger E homeobox binding family, promotes ABC differentiation by repressing alternative differentiative fates and targeting genes important for ABC character and function. Moreover, their results strengthen the case for causal links between ABC fate and function in autoimmune pathologies.
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| http://dx.doi.org/10.1111/imcb.12744 | DOI Listing |
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