AI Article Synopsis
- A 56-year-old woman presented with a painless mass in her chest that had been growing for 5 months and was accompanied by a skin rash, mild shortness of breath, and chest pain during position changes.
- Imaging revealed a large soft tissue mass influencing nearby structures, particularly causing bone damage, but no lymph node involvement was noted.
- Initial biopsy suggested histiocytic sarcoma, but further testing identified it as anaplastic large cell lymphoma with a specific genetic fusion, highlighting its rare and unique characteristics.
Article Abstract
A 56-year-old woman debuted with a palpable painless mass in the anterior thorax wall at the level of the second and third right parasternal intercostal space, which progressively increased in size over 5 months accompanied by localized skin rash, mild dyspnea and chest pain when changing position. Imaging studies showed a soft tissue mass measuring 75 × 62 mm and a density of 34 Hounsfield Units that had caused the lysis of the costal arches and grew expansively towards the anterior mediastinum, without identifying mediastinal adenopathies only by this imaging method. Core biopsy was performed, which was initially diagnosed as histiocytic sarcoma (HS); however, when the diagnostic panel was expanded to include molecular and NGS studies, the final diagnosis was anaplastic large cell lymphoma with ALK::ATIC fusion. Here, we report a very rare neoplasm with unusual clinical presentation, histopathology and molecular features.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062848 | PMC |
| http://dx.doi.org/10.1111/1759-7714.15293 | DOI Listing |
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