Prospective Randomized Pilot Trial on the Effects of Mild Hypercapnia on Cerebral Oxygen Saturation in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.

Objective And Design: A single-center prospective randomized controlled study was conducted to assess the effect of targeted mild hypercapnia (TMH) on cerebral oxygen saturation (rSO) in patients undergoing off-pump coronary artery bypass grafting (CABG).

Setting And Participants: A prospective randomized controlled study involving 100 patients undergoing off-pump CABG at U. N. Mehta Hospital, Ahmedabad, Gujarat, India.

Intervention: Patients were randomized to either the TMH (PaCO 45-55 mmHg) or the targeted normocapnia (TN; PaCO 35-45 mmHg) group, containing 50 patients in each group.

Measurements: Monitoring of rSO, heart rate, mean arterial pressure (MAP), PaCO, and peripheral oxygen saturation was done at baseline, after induction, after left internal mammary artery harvesting, at each grafting (distal and proximal), after protamine, and after shifting to the intensive care unit. The standardized minimental-state examination (SMMSE) was performed preoperatively and at 8, 12, and 24 hours postextubation. Data were analyzed using an independent sample t test.

Results: The TMH group had higher MAP during grafting (p < 0.001) and higher rSO on both sides during distal and proximal grafting (p < 0.001) and after protamine (p < 0.05), as compared to the TN group. Compared to preoperative values, SMMSE scores in the TN group were significantly lower at 12 and 24 hours postextubation (p < 0.001).

Conclusion: TMH during grafting increased the cerebral blood flow and rSO when hemodynamic instability was very common. It has a protective role on the brain and helps maintain cognition postoperatively.