AI Article Synopsis
- Ferulic acid (FA) has potential biological benefits but faces challenges with low solubility and stability, limiting its effectiveness; encapsulating it with hydroxypropyl-β-cyclodextrin (HP-β-CD) could improve this situation.
- Spectral analyses and computer simulations revealed that the inclusion complex between FA and HP-β-CD enhances its thermal stability, with evidence showing FA's effective incorporation into the HP-β-CD cavity.
- The study's findings offer insights into the FA/HP-β-CD interactions, pointing towards better delivery methods for FA and improving the bioavailability of otherwise insoluble active substances.
Article Abstract
Background: The biological functions of ferulic acid (FA) have garnered significant interest but its limited solubility and stability have led to low bioavailability. Hydroxypropyl-β-cyclodextrin (HP-β-CD), with its distinctive hollow structure, offers the potential for encapsulating hydrophobic molecules. The formation of an inclusion complex between FA and HP-β-CD may therefore be a viable approach to address the inherent limitations of FA. To investigate the underlying mechanism of the FA/HP-β-CD inclusion complex formation, a combination of spectral analyses and computer simulation was employed.
Results: The disappearance of the characteristic peaks of FA in Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) confirmed the formation of an inclusion complex between FA and HP-β-CD. Thermogravimetry-derivative thermogravimetry (TG-DTG) studies demonstrated that the thermal stability of FA was enhanced due to the encapsulation of FA within HP-β-CD. Molecular dynamics simulation also provided evidence that FA successfully penetrated the HP-β-CD cavity, primarily driven by van der Waals interactions. The formation of the complex resulted in more compact HP-β-CD structures. The bioavailability of FA was also strengthened through the formation of inclusion complexes with HP-β-CD.
Conclusions: The findings of this study have contributed to a deeper understanding of the interactions between FA and HP-β-CD, potentially advancing a delivery system for FA and enhancing the bioavailability of insoluble active components. © 2024 Society of Chemical Industry.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jsfa.13482 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Do Languages Have Exclusive Disjunctions?
Open Mind (Camb)
December 2024
Universidade de Lisboa, Centro de Linguística, Lisbon, Portugal.
Most natural languages have more than one linguistic form available to express disjunction. One of these forms is often reported by native speakers to be more exclusive than the other(s) and, in recent years, it has been claimed that some languages may in fact have dedicated exclusive disjunctions. In this paper, we report on a series of experiments testing this claim across five languages of primary interest.
View Article and Find Full Text PDFSpinal cord stimulation for the treatment of complex regional pain syndrome: A systematic review of randomized controlled trials.
Interv Pain Med
December 2024
Department of Physical and Rehabilitation Medicine, University of Turku, Turku, Finland.
Background: Spinal Cord Stimulation (SCS) is a widely recognized treatment for Complex Regional Pain Syndrome (CRPS), particularly in cases where traditional methods are ineffective. This paper systematically reviews randomized controlled trials to analyze the efficacy of SCS, as well as Dorsal Root Ganglion (DRG) Stimulation in treating CRPS, focusing on its long-term effectiveness.
Methods: This systematic review focused exclusively on randomized controlled trials to assess a primary outcome of improvement in pain symptoms in patients diagnosed with CRPS.
Apathy Associated with Alzheimer's Disease.
Curr Alzheimer Res
December 2024
Department of Neuroscience, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Introduction/objective: Apathy is a multidimensional and complex disease that is the primary neuropsychiatric symptom among those diagnosed with Alzheimer's disease (AD). Yet, apathy in AD is sometimes underestimated.
Methods: A systematic literature review was conducted using databases such as PubMed, Scopus, and Web of Science.
Modeling cancer-microbiome interactions in vitro: A guide to co-culture platforms.
Int J Cancer
December 2024
Junior Research Group Epithelium Microbiome Interactions (EMIL), German Cancer Research Center, Heidelberg, Germany.
The biology of cancer is characterized by an intricate interplay of cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggested to be enriched in tumors and the impacts of these on tumor phenotypes is subject to intensive investigation. For these efforts, model systems that accurately reflect human-microbe interactions are rapidly gaining importance.
View Article and Find Full Text PDFAPA/APAGS Award for Distinguished Graduate Student in Professional Psychology: Sarah C. Leighton.
Am Psychol
December 2024
The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. Sarah C. Leighton is a joint winner of the 2024 awawrd, in recognition of her outstanding practice and application of psychology through her exemplary work with individuals with disabilities and service dogs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!