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Outcomes of Modulator Therapy Discontinued After Short-Term Use in Adult Cystic Fibrosis.
Pediatr Pulmonol
January 2025
Department of Chest Diseases, Division of Allergy and Clinical Immunology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Article Synopsis
- CFTR-MT therapies significantly improved pulmonary function and reduced exacerbations in adult cystic fibrosis patients during treatment, as evidenced by substantial increases in FEV1 and FVC levels.
- The study monitored 33 patients, revealing that the benefits of these therapies diminished after stopping the medication, with marked declines in lung function and increased exacerbation rates post-treatment.
- The findings emphasize the need for consistent access to CFTR-MTs, as interruptions due to reimbursement issues can lead to negative health impacts for patients.
Fluconazole-loaded Hyaluronic Acid-modified Transfersomal Hydrogels Containing D-panthenol for Ocular Delivery in Fungal Keratitis Management.
Curr Drug Deliv
October 2024
Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, 751003, Odisha, India.
Background: Fungal keratitis (mycotic keratitis) is an eye infection in which the cornea is infected by fungi and such fungal keratitis management can be effectively possible by ocular administration of antifungal drugs.
Objective: The main objectives of the present research were to develop and evaluate fluconazoleloaded transfersomal hydrogels for ocular delivery in the effective management of fungal keratitis.
Methods: A 23 factorial design-based approach was used for statistical optimization, where (A) the ratio of lipid to edge activators, (B) the amount of hyaluronic acid (% HA), and (C) the ratio of edge activators (sodium deoxycholate to Span 80) were taken as three factors.
[Ga]Ga-Schizokinen, a Potential Radiotracer for Selective Bacterial Infection Imaging.
ACS Infect Dis
August 2024
Institute of Pharmaceutical Science, Faculty of Life Science and Medicine, King's College London, London SE1 9NH, United Kingdom.
Gallium-68-labeled siderophores as radiotracers have gained interest for the development of infection-specific imaging diagnostics. Here, we report radiolabeling, screening, and pharmacokinetics (PK) of gallium-68-labeled schizokinen ([Ga]Ga-SKN) as a new potential radiotracer for imaging bacterial infections. We radiolabeled SKN with ≥95% radiochemical purity.
View Article and Find Full Text PDF[Expert consensus on the diagnosis and treatment of pulmonary aspergillosis in patients with chronic obstructive pulmonary disease].
Zhonghua Jie He He Hu Xi Za Zhi
July 2024
The prevalence of pulmonary aspergillosis is increasing in patients with chronic obstructive pulmonary disease (COPD) and can manifest in different forms such as invasive pulmonary aspergillosis (IPA), chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA). With the variations of individual conditions such as immune status, these forms of the disease may transform into each other or even overlap. Moreover, the atypical clinical manifestations and the limited use of invasive sampling techniques have posed a challenge to the diagnosis and treatment of invasive pulmonary aspergillosis in patients with COPD.
View Article and Find Full Text PDFAflatoxins in Peanut (): Prevalence, Global Health Concern, and Management from an Innovative Nanotechnology Approach: A Mechanistic Repertoire and Future Direction.
ACS Omega
June 2024
College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, Jiangsu, China.
Article Synopsis
- Peanuts are a crucial oilseed legume crop providing nutrition and affordable protein, but their production is threatened by aflatoxin contamination due to fungal infections.
- Traditional storage methods are limited, prompting the need for effective long-term solutions to reduce aflatoxin levels in peanuts, which is vital for food safety and health.
- Innovative nano-technology presents a promising approach, functioning as nanofungicides that target and eliminate fungal infections, thereby enhancing peanut quality and safety while connecting farmers to larger markets.
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