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RSV Vaccine with Nanoparticle-Based Poly-Sorbitol Transporter (PST) Adjuvant Improves Respiratory Protection Against RSV Through Inducing Both Systemic and Mucosal Humoral Immunity.
Vaccines (Basel)
November 2024
Department of Systems Biotechnology, Chung-Ang University, Anseong 17456, Republic of Korea.
Respiratory syncytial virus (RSV) causes symptoms similar to a mild cold for adults, but in case of infants, it causes bronchitis and/or pneumonia, and in some cases, mortality. Mucosal immunity within the respiratory tract includes tissue-resident memory T (T) cells and tissue-resident memory B (B) cells, which provides rapid and efficient protection against RSV re-infection. Therefore, vaccine strategies should aim to generate mucosal immune responses.
View Article and Find Full Text PDFNeurotransmitter Metabolic Disturbance in Methamphetamine Abusers: Focus on Tryptophan and Tyrosine Metabolic Pathways.
Toxics
December 2024
Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Methamphetamine (METH) abuse disrupts the homeostasis of neurotransmitter (NT) metabolism, contributing to a wide range of neurological and psychological disorders. However, the specific effects of METH on NT metabolism, particularly for the tryptophan (TRP) and tyrosine (TYR) metabolic pathways, remain poorly understood. In this study, serum samples from 78 METH abusers and 79 healthy controls were analyzed using Ultra-High-Performance Liquid Chromatography with Tandem Mass Spectrometry (UHPLC-MS/MS).
View Article and Find Full Text PDFPredictive Feasibility of the Graz Malnutrition Screening, Controlling Nutritional Status Score, Geriatric Nutritional Risk Index, and Prognostic Nutritional Index for Postoperative Long-Term Mortality After Surgically Treated Proximal Femur Fracture.
Nutrients
December 2024
Clinical Division of Traumatology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Background: Hip fractures are a prevalent and serious health issue, particularly among the elderly population aged >65 years. These injuries are associated with elevated rates of postoperative complications and mortality, significantly diminishing patients' quality of life in both the short- and long-term. The prognosis for recovery is further exacerbated in individuals with signs of malnutrition.
View Article and Find Full Text PDFExploring Metal-Metal Composites: A Study on AA5083 Matrix-Cr Particles Reinforced Composites.
Materials (Basel)
December 2024
Faculty of Engineering, Metallurgical and Materials Engineering, Karadeniz Technical University, 61080 Trabzon, Turkey.
The objective of this study is to develop chromium-reinforced metal-metal composites utilizing an AA5083 aluminum alloy matrix through powder metallurgy while also examining their properties. Samples were produced by incorporating varying quantities of chromium (5%, 10%, and 15% by weight) into the AA5083 matrix. In order to ensure a uniform distribution of chromium particles, the powders were blended in a ball mill and subsequently hot-pressed at 500 °C under 500 MPa for a period of two hours in an argon atmosphere.
View Article and Find Full Text PDFExploring the Impact of IL-33 Gene Polymorphism () on Susceptibility to Chronic Spontaneous Urticaria and Its Association with Serum Interleukin-33 Levels.
Int J Mol Sci
December 2024
Department of Anatomy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Urticaria is a debilitating skin condition affecting up to 20% of the global population, characterized by erythematous, maculopapular lesions and significant quality of life impairment. This study focused on the role of interleukin 33 (IL-33) and its polymorphisms, particularly SNP , in chronic spontaneous urticaria (CSU). Using demographic, clinical, and laboratory data from CSU patients and controls, we estimated allele and genotype frequencies, Hardy-Weinberg equilibrium condition, and serum IL-33 levels, using unconditional binomial logistic regression for association analysis.
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