AI Article Synopsis
- The study investigates how oral antivirals and vaccinations impact the risk of death and severe illness from COVID-19 among hospitalized patients in Hong Kong.
- It used an advanced statistical model to obtain unbiased estimates of these interventions' effects, focusing on patients diagnosed with COVID-19 between March and December 2022.
- Results showed that nirmatrelvir-ritonavir significantly reduces mortality and severe outcomes compared to molnupiravir, while no notable differences were found between the CoronaVac and Comirnaty vaccines.
Article Abstract
Objectives: This study aims to estimate the causal effects of oral antivirals and vaccinations in the prevention of all-cause mortality and progression to severe COVID-19 in an integrative setting with both antivirals and vaccinations considered as interventions.
Methods: We identified hospitalized adult patients (i.e. aged 18 or above) in Hong Kong with confirmed SARS-CoV-2 infection between March 16, 2022, and December 31, 2022. An inverse probability-weighted (IPW) Andersen-Gill model with time-dependent predictors was used to address immortal time bias and produce causal estimates for the protection effects of oral antivirals and vaccinations against severe COVID-19.
Results: Given prescription is made within 5 days of confirmed infection, nirmatrelvir-ritonavir is more effective in providing protection against all-cause mortality and development into severe COVID-19 than molnupiravir. There was no significant difference between CoronaVac and Comirnaty in the effectiveness of reducing all-cause mortality and progression to severe COVID-19.
Conclusions: The use of oral antivirals and vaccinations causes lower risks of all-cause mortality and progression to severe COVID-19 for hospitalized SARS-CoV-2 patients.
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| http://dx.doi.org/10.1016/j.ijid.2024.107012 | DOI Listing |
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