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Exploring the impact of exercise on women with ovarian cancer: A call for more methodologically standardized RCTs to enable a realistic systematic review.
Eur J Surg Oncol
December 2024
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Malta.
Introduction: Ovarian cancer remains a leading cause of mortality among gynecological malignancies, often diagnosed at advanced stages due to nonspecific symptoms and limited screening tools. Standard treatment, including cytoreductive surgery and chemotherapy, can cause fatigue, physical dysfunction, and psychological distress, impacting quality of life. Exercise interventions have shown potential to mitigate these effects, but inconsistent methodologies in randomized controlled trials (RCTs) limit reliable conclusions and clinical integration.
View Article and Find Full Text PDFA multivariate analysis to explain residue errors in pathogen concentration in wastewater-based epidemiology.
Sci Total Environ
December 2024
Leibniz Universität Hannover, 30459 Hannover, Germany. Electronic address:
With the beginning of the COVID-19 pandemic, wastewater-based epidemiology (WBE), which according to Larsen et al. (2021), describes the science of linking pathogens and chemicals found in wastewater to population-level health, received an enormous boost worldwide. The basic procedure in WBE is to analyse pathogen concentrations and to relate these measurements to cases from clinical data.
View Article and Find Full Text PDFDifferential impact of lifestyle factors on 2-hour glucose values in individuals with type 2 diabetes: potential for more personalized interventions.
BMJ Open Diabetes Res Care
December 2024
Endocrinology, Leiden Universitair Medisch Centrum, Leiden, Netherlands.
Introduction: Lifestyle determinants of 2-hour glucose concentration in people with type 2 diabetes and interindividual differences need to be identified.
Research Design And Methods: 38 participants with type 2 diabetes, treated with lifestyle advice and/or metformin, tracked their physical activity, sleep and dietary intake, while continuously monitoring interstitial glucose concentrations for 11 periods of four consecutive days each. A linear mixed-effects model was used to quantify the effect of sleep, stress, current glucose, carbohydrate intake and exercise on glucose levels 2 hours later.
A one-day acceptance and commitment therapy workshop for the prevention of chronic post-surgical pain and long-term opioid use following spine surgery: Protocol for a pilot feasibility randomized controlled trial.
Contemp Clin Trials
December 2024
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Background: Back pain is increasingly common, leading to more spine surgeries. While most people experience pain relief and improved function after surgery, many continue to suffer from chronic post-surgical pain (CPSP) with limited functional improvement. CPSP is often treated with opioids, raising concerns about misuse, poor functional outcomes, and broader public health impacts.
View Article and Find Full Text PDFThe Caregiver Pathway Intervention Can Contribute to Reduced Post-Intensive Care Syndrome Among Family Caregivers of ICU Survivors: A Randomized Controlled Trial.
Crit Care Med
December 2024
Department of Digital Health Research, Division of Medicine, Oslo University Hospital, Oslo, Norway.
Objectives: Explore short-term effects of "The Caregiver Pathway," an intervention for family caregiver follow-up, on Post-Intensive Care Syndrome symptoms among families (PICS-F).
Design: A randomized controlled trial.
Setting: A medical ICU at a Norwegian University Hospital.
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