Emerging and re-emerging pathogens are latent threats in our society with the risk of killing millions of people worldwide, without forgetting the severe economic and educational backlogs. From COVID-19, we learned that self isolation and quarantine restrictions (confinement) were the main way of protection till availability of vaccines. However, abrupt lifting of social confinement would result in new waves of new infection cases and high death tolls. Here, inspired by how an extracellular solution can make water move into or out of a cell through osmosis, we define confinement tonicity. This can serve as a standalone measurement for the net direction and magnitude of flows between the confined and deconfined susceptible compartments. Numerical results offer insights on the effects of easing quarantine restrictions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11067545 | PMC |
| http://dx.doi.org/10.1007/s00285-024-02064-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Confinement tonicity on epidemic spreading.
J Math Biol
March 2024
Department of Mathematics and Statistical Science, University of Idaho, Moscow, ID, 83844-1103, USA.
Emerging and re-emerging pathogens are latent threats in our society with the risk of killing millions of people worldwide, without forgetting the severe economic and educational backlogs. From COVID-19, we learned that self isolation and quarantine restrictions (confinement) were the main way of protection till availability of vaccines. However, abrupt lifting of social confinement would result in new waves of new infection cases and high death tolls.
View Article and Find Full Text PDFT cell migration in microchannels densely packed with T cells.
Sci Rep
May 2019
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH) San 31, Hyoja-dong, Nam-Gu, Pohang, Gyeongbuk, 37673, Korea.
T cells migrate diverse microenvironments of the body to mount antigen-specific immune responses. T cell activation, a key initial process for antigen-specific immune responses, occur in secondary lymphoid organs such as spleens and lymph nodes where high density of T cells migrates rapidly through the reticular networks formed by stromal cells. In vitro model system recapitulating key characteristics of secondary lymphoid organs, confined spaces densely packed with rapidly migrating cells, would be useful to investigate mechanisms of T cell migration.
View Article and Find Full Text PDFOsmolality/salinity-responsive enhancers (OSREs) control induction of osmoprotective genes in euryhaline fish.
Proc Natl Acad Sci U S A
March 2017
Biochemical Evolution Laboratory, Department of Animal Science, University of California, Davis, CA, 95616;
Fish respond to salinity stress by transcriptional induction of many genes, but the mechanism of their osmotic regulation is unknown. We developed a reporter assay using cells derived from the brain of the tilapia (OmB cells) to identify osmolality/salinity-responsive enhancers (OSREs) in the genes of Genomic DNA comprising the regulatory regions of two strongly salinity-induced genes, inositol monophosphatase 1 () and -inositol phosphate synthase (), was isolated and analyzed with dual luciferase enhancer trap reporter assays. We identified five sequences (two in and three in ) that share a common consensus element (DDKGGAAWWDWWYDNRB), which we named "OSRE1.
View Article and Find Full Text PDFReduced tonicity stimulates an inflammatory response in nucleus pulposus tissue that can be limited by a COX-2-specific inhibitor.
J Orthop Res
November 2015
Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
In intervertebral disc herniation with nucleus pulposus (NP) extrusion, the elicited inflammatory response is considered a key pain mechanism. However, inflammatory cytokines are reported in extruded herniated tissue, even before monocyte infiltration, suggesting that the tissue itself initiates the inflammation. Since herniated tissue swells, we investigated whether this simple mechanobiological stimulus alone could provoke an inflammatory response that could cause pain.
View Article and Find Full Text PDFModulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience.
Proc Natl Acad Sci U S A
December 2005
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.
Biological properties of renal-specific oxidoreductase (RSOR), characteristics of its promoter, and underlying mechanisms regulating its expression in diabetes were analyzed. RSOR expression, normally confined to the renal cortex, was markedly increased and extended into the outer medullary tubules in db/db mice, a model of type 2 diabetes. Exposure of LLCPK cells to d-glucose resulted in a dose-dependent increase in RSOR expression and its enzymatic activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!