AI Article Synopsis
- The article discusses collagen-gelatin and its gelation process, focusing on how blending with polysaccharides can enhance mucoadhesion and retention in the gastrointestinal tract.
- It highlights the significance of the interactions between mucoadhesive materials and mucin layers for effective drug delivery and biomedical applications.
- The research emphasizes the biocompatibility and biodegradability of collagen/gelatin-polysaccharide blends, which show promising mucoadhesive properties due to their electrostatic interactions with mucin glycoproteins.
Article Abstract
This article has focused on collagen-gelatin, the gelation process, as well as blend interaction between collagen/gelatin with various polysaccharides to boost mucoadhesion and gastric retention. The interaction between mucoadhesive materials and mucin layers is of significant interest in the development of drug delivery systems and biomedical applications for effective targeting and prolonged time in the gastrointestinal tract. This paper reviews the current advancement and mucoadhesive properties of collagen/gelatin and different polysaccharide complexes concerning the mucin layer and interactions are briefly highlighted. Collagen/gelatin and polysaccharide blends biocompatible and biodegradable, the complex biomolecules have shown encouraging mucoadhesive properties due to their cationic nature and ability to form hydrogen bonds with mucin glycoproteins. The mucoadhesion mechanism was attributed to the electrostatic interactions between the positively charged amino (NH) groups of blend biopolymers and the negatively charged sialic acid residues present in mucin glycoprotein. At the end of this article, the encouraging prospect of collagen/polysaccharide complex and mucin glycoprotein is highlighted.
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| http://dx.doi.org/10.1016/j.ijbiomac.2024.131034 | DOI Listing |
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