We present an investigation of the interpad region (IP) in the Ultra-Fast Silicon Detector (UFSD) Type 10, utilizing a femtosecond laser and the transient current technique (TCT). We elucidate the isolation structure and measure the IP distance between pads, comparing it to the nominal value provided by the vendor. A comparison of sensors with identical layouts but different nominal IP distances (49 μm vs. 61 μm) and different processing parameters revealed their significant different charge collection properties in the IP.
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http://dx.doi.org/10.1016/j.apradiso.2024.111288 | DOI Listing |
Front Immunol
January 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Introduction: Hematopoietic stem cell transplantation (HSCT) and chemotherapy are considered potentially curative options for post-remission therapy in acute myeloid leukemia (AML). However, the comparative effectiveness of these approaches in favorable- and intermediate-risk AML remains unclear and requires further investigation.
Methods: In this retrospective study, 111 patients diagnosed with de novo favorable- and intermediate-risk AML, categorized according to the ELN 2022 guidelines, were investigated to compare outcomes following autologous HSCT (auto-HSCT), matched sibling donor HSCT (MSD-HSCT), and chemotherapy.
Front Pharmacol
January 2025
Hubei Shizhen Laboratory, Wuhan, China.
Introduction: The mortality rate for liver cancer is extremely high but clinical treatments have not made much progress, so it is necessary to develop anticancer agents with lower toxicities and more effective liver-targeting drug delivery systems (LTDDSs). At present, LTDDSs mediated by the asialoglycoprotein receptor (ASGPR) show excellent effects at improving the liver-targeting and antitumor effects of drugs. However, the galactosyl ligands are typically prepared by chemical synthesis and have some shortcomings.
View Article and Find Full Text PDFFront Public Health
January 2025
School of Computer Science and Technology, Zhengzhou University of Light Industry, Zhengzhou, China.
The accuracy of spatial clustering detection is crucial for public health policy development and identifying etiological clues. Circular and flexibly-shaped scan statistics are widely used for disease cluster detection, but differences in results arise mainly due to parameter sensitivity and variations in the scanning window shapes. This study aims to analyze the impact of parameter settings on the results of these methods and compare their performance in disease clustering detection.
View Article and Find Full Text PDFFront Aging Neurosci
January 2025
Department of Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: The perception of Subjective Visual Vertical (SVV) is crucial for postural orientation and significantly reflects an individual's postural control ability, relying on vestibular, visual, and somatic sensory inputs to assess the Earth's gravity line. The neural mechanisms and aging effects on SVV perception, however, remain unclear.
Objective: This study seeks to examine aging-related changes in SVV perception and uncover its neurological underpinnings through functional near-infrared spectroscopy (fNIRS).
Surg Pract Sci
March 2025
Arizona Center of Hand to Shoulder Surgery, Phoenix, AZ, United States.
Introduction: Time spent in the operating room (OR) has ramifications that impact patient outcomes and the economics of patients, physicians, surgery centers, and insurance industry. For that reason, there is an incentive to seek approaches that allow shorter times to be spent in the OR. To what extent varying routine techniques impact on operating times has not been extensively studied in metacarpal fixation literature, specifically investigating retrograde threaded intramedullary nail fixations (RTNF) and comparing it to open plating fixations (OPF).
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