AI Article Synopsis
- There is an urgent need for engineered scaffolds to help form and maintain adipose tissue for surgical use.
- Researchers optimized adipose regeneration methods and created decellularized adipose tissue (DAT) scaffolds that are biocompatible.
- The study demonstrated that using DAT with preadipocytes promotes the growth and differentiation of new adipose tissue, showing promise for future applications in clinical tissue engineering.
Article Abstract
There is currently an urgent need to develop engineered scaffolds to support new adipose tissue formation and facilitate long-term maintenance of function and defect repair to further generate prospective bioactive filler materials capable of fulfilling surgical needs. Herein, adipose regeneration methods were optimized and decellularized adipose tissue (DAT) scaffolds with good biocompatibility were fabricated. Adipose-like tissues were reconstructed using the DAT and 3T3-L1 preadipocytes, which have certain differentiation potential, and the regenerative effects of the engineered adipose tissuesandwere explored. The method improved the efficiency of adipose removal from tissues, and significantly shortened the time for degreasing. Thus, the DAT not only provided a suitable space for cell growth but also promoted the proliferation, migration, and differentiation of preadipocytes within it. Following implantation of the constructed adipose tissues, the DAT showed gradual degradation and integration with surrounding tissues, accompanied by the generation of new adipose tissue analogs. Overall, the combination of adipose-derived extracellular matrix and preadipocytes for adipose tissue reconstruction will be of benefit in the artificial construction of biomimetic implant structures for adipose tissue reconstruction, providing a practical guideline for the initial integration of adipose tissue engineering into clinical medicine.
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| http://dx.doi.org/10.1088/1748-605X/ad3705 | DOI Listing |
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