AI Article Synopsis
- Male cancer patients undergoing antineoplastic therapy often experience hypogonadism, which negatively affects their quality of life, though its causes related to cancer treatment are not well understood.
- A systematic review identified 28 studies that indicated certain drugs, like anti-angiogenic agents and platinum salts, contribute to hypogonadism, with immune checkpoint inhibitors causing secondary hypogonadism due to immune reactions.
- The findings highlight the need for regular evaluation of hormonal levels in at-risk patients before and during treatment to better manage this condition.
Article Abstract
Background: In male patients with cancer treated with antineoplastic drug, hypogonadism is a neglected cause of diminished quality of life. This condition may be cancer related as well as toxicity related. The role of antineoplastic drug in causing hypogonadism is poorly understood. The aim of this systematic review was to establish the prevalence, nature (primary/secondary), and impact of hypogonadism on quality of life in male patients with cancer on antineoplastic therapy.
Methods: The search strategy used PubMed, Embase, and Cochrane databases to select articles in English language that described hypogonadism in male patients with cancer. The search period was from January 1, 1945 to February 28, 2023. We included observational studies, case reports or case series and excluded studies concerning hematological malignancies, prostate cancer, female patients, and survivors.
Findings: Of 4488 records identified, 28 studies met inclusion criteria (17 observational studies, 11 case reports or case series). Anti-angiogenic drugs and crizotinib were found to have a role in the development of hypogonadism. Patients treated with immune checkpoint-inhibitors developed secondary hypogonadism due to immune-related hypophysitis or orchitis. As for active chemotherapy, platinum salts were often associated with hypogonadism, followed by antimetabolites and taxanes. Selected studies were heterogeneous for populations, interventions, and outcomes assessments. Thus, a generalization is difficult. Moreover, the role of concurrent etiologies cannot be excluded in most studies.
Conclusion: Our research emphasizes the importance of evaluating the gonadal axis before treatment in patients considered at risk and testing it at regular intervals or in case of clinical suspicion.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145017 | PMC |
| http://dx.doi.org/10.1093/oncolo/oyae024 | DOI Listing |
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