Challenges, risks, and opportunities of antiretroviral drugs in women of reproductive potential.

Expert Rev Anti Infect Ther

Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Published: April 2024

AI Article Synopsis

  • The HIV/AIDS epidemic poses major challenges for women's health, but advancements in antiretroviral therapy have improved their quality of life and reduced risks in reproductive health.
  • Despite these improvements, access to and adherence to these treatments remain issues, highlighting the need for more research on the effects of antiretrovirals during pregnancy and breastfeeding.
  • Innovative solutions like multipurpose technologies and long-acting medications could help improve treatment adherence and health outcomes for women living with HIV, alongside necessary advancements in drug safety testing.

Article Abstract

Introduction: The HIV/AIDS epidemic has been one of the greatest challenges in global health, significantly affecting women of reproductive potential. Considerable advances in antiretroviral therapy for women living with HIV have contributed to improvements in quality of life, better reproductive and birth outcomes, and a reduced risk of perinatal transmission.

Areas Covered: Despite the progress made, persistent challenges in access and adherence to antiretroviral drugs may limit their benefits for some women. More pharmacokinetic and safety studies in pregnant and lactating women are urgently needed, as are prospective surveillance systems to evaluate associations between fetal and infant antiretroviral exposures, drug-drug interactions, and pregnancy outcomes.

Expert Opinion: Multipurpose technologies, such as combined HIV and other STI or unintended pregnancy prevention, and innovative delivery methods, such as the development of long-acting antiretrovirals, have the potential to reduce adherence challenges and enhance quality of life for women with HIV. Parallel advances in drug safety testing and surveillance are needed to ensure the health and safety of women with or at risk for HIV and children at risk for perinatal transmission.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287786PMC
http://dx.doi.org/10.1080/14787210.2024.2334054DOI Listing

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