AI Article Synopsis
- Nitroxyl (HNO) is important for biological functions and drug activities, making it essential to develop effective detection tools for studying its role in health and disease.
- A new dual-modality probe called QL-HNO was created by modifying hemicyanine to improve sensitivity in near-infrared fluorescent (NIRF) and photoacoustic (PA) imaging for detecting HNO both externally and internally.
- QL-HNO demonstrated excellent performance in living cells and tumor models, suggesting it could be a valuable tool for advancing research on the physiological and pathological impacts of HNO.
Article Abstract
Nitroxyl (HNO) plays a vital role in various biological functions and pharmacological activities, so the development of an excellent near-infrared fluorescent (NIRF) and photoacoustic (PA) dual-modality probe is crucial for understanding HNO-related physiological and pathological progression. Herein, we proposed and synthesized a novel NIRF/PA dual probe (QL-HNO) by substituting an indole with quinolinium in hemicyanine for the sensitive detection of exogenous and endogenous HNO . The designed probe showed the highest sensitivity in NIRF mode and a desirable PA signal-to-noise ratio for HNO detection and was further applied for NIRF/PA dual-modal imaging of HNO with high contrast in living cells and tumor-bearing animals. Based on the excellent performance of QL-HNO, we believe that this study provides a promising molecular tool for further understanding of HNO-related physiological and pathological progression.
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| http://dx.doi.org/10.1039/d4an00188e | DOI Listing |
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