For the calculation of sample size for a randomized controlled clinical trial, choosing a proper, medium clinically meaningful difference in the size of the effect of the test and control interventions is important for avoiding too small or too large sample sizes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10951484PMC
http://dx.doi.org/10.1002/ped4.12415DOI Listing

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