AI Article Synopsis
- - Cardiovascular diseases are significant contributors to global health issues, with cytokines and proteins playing essential roles in their complexity and variability.
- - The thrombospondin (TSP) family, consisting of five members divided into two groups, is crucial for cell interactions and impacts the extracellular matrix in the cardiovascular system.
- - Recent research highlights the importance of TSPs, particularly TSP-5, and suggests that targeting these proteins may offer substantial therapeutic benefits for cardiovascular diseases and other related conditions.
Article Abstract
Cardiovascular diseases have been identified as vital factors in global morbidity and mortality in recent years. The available evidence suggests that various cytokines and pathological proteins participate in these complicated and changeable diseases. The thrombospondin (TSP) family is a series of conserved, multidomain calcium-binding glycoproteins that cause cell-matrix and cell-cell effects via interactions with other extracellular matrix components and cell surface receptors. The TSP family has five members that can be divided into two groups (Group A and Group B) based on their different structures. TSP-1, TSP-2, and TSP-4 are the most studied proteins. Among recent studies and findings, we investigated the functions of several family members, especially TSP-5. We review the basic concepts of TSPs and summarize the relevant molecular mechanisms and cell interactions in the cardiovascular system. Targeting TSPs in CVD and other diseases has a remarkable therapeutic benefit.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954798 | PMC |
| http://dx.doi.org/10.3389/fcvm.2024.1337586 | DOI Listing |
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