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ZDHHC2 promoted antimycobacterial responses by selective autophagic degradation of B-RAF and C-RAF in macrophages.
Sci Adv
January 2025
Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
S-Palmitoylation is a reversible post-translational modification involving saturated fatty acid palmitate-to-cysteine linkage in the protein, which guides many aspects of macrophage physiology in health and disease. However, the precise role and underlying mechanisms of palmitoylation in infection of macrophages remain elusive. Here, we found that infection induced the expression of zinc-finger DHHC domain-type palmitoyl-transferases (ZDHHCs), particularly ZDHHC2, in mouse macrophages.
View Article and Find Full Text PDFBuilding Spatiotemporal Understanding of -Host Interactions.
ACS Infect Dis
January 2025
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, United States.
Heterogeneity during (Mtb) infection greatly impacts disease outcome and complicates treatment. This heterogeneity encompasses many facets, spanning local differences in the host immune response to Mtb and the environment experienced by the bacterium, to nonuniformity in Mtb replication state. All of these facets are interlinked and each can affect Mtb susceptibility to antibiotic treatment.
View Article and Find Full Text PDFBeyond the Lung: A Rare Presentation of Tuberculosis in the Tarsometatarsal Joint Treated With Chemotherapy, Surgical Debridement, and Fusion.
Cureus
December 2024
Orthopaedics and Traumatology, District Headquarters Hospital, Cuddalore, IND.
Foot tuberculosis is rarely reported in the literature, with most tuberculosis of the foot being an uncommon manifestation of skeletal tuberculosis. Early diagnosis and timely medical and surgical intervention can significantly reduce morbidity. A 23-year-old male presented with persistent swelling and pain in his right foot for six months, accompanied by a discharging sinus over the affected area in the last week, making weight-bearing increasingly difficult.
View Article and Find Full Text PDFTuberculous adrenal abscess revealed by pleurisy: An extremely rare presentation: About a case.
Urol Case Rep
January 2025
Emergency Radiology Department, Avicenne Hospital, Mohammed V University, Rabat, Morocco.
We report an extremely rare presentation of a tuberculous adrenal abscess discovered accidently during a chest CT scan. This case involves a 21-year-old male patient with pleurisy and a left adrenal abscess simultaneously of tuberculous origin, without clinical or biological signs of adrenal insufficiency. The condition showed complete regression of the abscess after medical treatment.
View Article and Find Full Text PDFHistorical examination of tuberculosis; from ancient affliction to modern challenges.
J Infect Public Health
January 2025
Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran. Electronic address:
Tuberculosis (TB), white plague, many other definitions is an ancient deadly infection that humans dealt with after creation. The first hypothesis refers to 150 million years ago about the appearance of TB in the Jurassic era before human creation, but documents show 9000 years ago for first appearance in human society. In 1882, Robert Koch was able to identify and describe the best possible agent of TB.
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