Recently licensed subunit vaccines represent the first and, thus far, the only approved agents for vaccination against malaria. However, these vaccines still fail to confer highly effective long-lasting protective immunity. Whole-organism vaccines, employing attenuated sporozoites as immunization agents, constitute a promising alternative for highly effective malaria vaccination. In this issue of , Goswami et al (2024) report on the generation and pre-clinical characterization of genetically attenuated parasites, termed LARC2, whose development arrests at late stages of liver infection. Their results warrant the clinical evaluation of PfSPZ-LARC2 towards its use as a whole-organism vaccine against malaria.
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| http://dx.doi.org/10.1038/s44321-024-00056-8 | DOI Listing |
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